New Chiral Molecular Tweezers with a Bis-Tröger's Base Skeleton†

Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, E-28040 Madrid, Spain.
The Journal of Organic Chemistry (Impact Factor: 4.72). 02/2001; DOI: 10.1021/jo0010882


A convenient synthesis of 5α,8α,14α,17α-5,17:8,14-dimethano-5,8,14,17-tetraaza-5,6,7,8,13,14,17,18-octahydrodibenzo[e,e‘]benzo[1,2-a:3,4-a‘]dicyclooctene derivatives is described, and the compounds have been fully characterized by NMR; in some cases, the molecular structure has been determined by X-ray crystallography. These compounds represent the first examples of a new class of molecular tweezers.

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