Influence of hepatic resection margin on recurrence and survival in intrahepatic cholangiocarcinoma
ABSTRACT Intrahepatic cholangiocarcinoma (ICC) is a rare disease in the Western world, hence little is known about its optimal surgical management. We analyzed whether hepatic resection margin is a prognostic factor for local or distant recurrence and survival in patients resected with curative intent.
Seventy-four patients underwent potentially curative surgery for ICC at our institution from 1994 to 2007. Demographic, and tumor- and surgery-related details including hepatic resection margin were recorded, patients were followed up for recurrence and survival. All patients were resected using modern dissection devices (CUSA or Waterjet).
Fifty-nine patients (80%) underwent R0 resection, 15 (20%) had a resection margin greater than 10 mm (wide margin, WM) and 38 (51%) between 1 and 10 mm (close margin, CM). In 14 patients (19%), hepatic resection margin was involved on histological examination; perioperative mortalities were excluded from analysis (n = 7). Forty-seven patients developed recurrence (WM, CM, and R1): hepatic recurrence was observed in 40%, 58%, and 50% of patients; extrahepatic spread occurred in 27, 16, and 14%; and 33, 26, and 36% had no recurrence of disease so far (P = 0.755). There was no difference between groups regarding local versus disseminated hepatic recurrence. Median recurrence free survival was 11.4 months (WM), 9.8 months (CM), and 9.9 months (R1), respectively (P = 0.880). Median overall survival was 27.2 months (WM), 29.7 months (CM), and not reached in the R1 group, (P = 0.350).
Hepatic resection margin seems to play a minor role in the prognosis of ICC as long as complete tumor clearance can be achieved with a modern liver dissection technique.
- SourceAvailable from: Timothy M Pawlik
Journal of Hepatology 06/2014; 60(6). DOI:10.1016/j.jhep.2014.01.021 · 10.40 Impact Factor
- "However, patients with unresectable CCA typically have significantly higher CA 19-9 levels compared with patients with resectable CCA . Other studies have noted that preoperative CA 19-9 values greater than 100 U/ml were also associated with worse recurrence-free survival after surgical resection . Bile duct obstruction or acute cholangitis may affect CA 19-9 levels. "
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- "In a recent series of 74 resected patients with ICC, Tamandl et al. stated that the median time between tumor recurrence and death was 16.4 months, and suggested that it might be increased by the use of a palliative treatment schedule . "
ABSTRACT: Percutaneous radiofrequency ablation (RFA) has shown efficacy in patients with recurrent hepatocellular carcinoma, but has not been well documented in patients with recurrent intrahepatic cholangiocarcinoma (ICC). We therefore evaluated the long-term survival and safety of percutaneous RFA for patients with recurrent ICC after curative resection. A total of 20 patients with 29 recurrent ICCs underwent ultrasound-guided percutaneous RFA. All patients had undergone curative resection of the primary ICC. Tumor size ranged from 0.7 cm to 4.4 cm in maximum dimension (mean, 1.9 cm; median, 1.5 cm). The technical effectiveness rate of RFA was 97% (28/29) of recurrent ICCs. Mean local tumor progression-free survival was 39.8 months, and the cumulative local tumor progression-free 6 month and 1, 2, and 4 year survival rates were 93%, 74%, 74%, and 74%, respectively. Median overall survival after RFA was 27.4 months and the cumulative overall 6 month and 1, 2, and 4 year survival rates were 95%, 70%, 60%, and 21%, respectively. There were two major complications (one liver abscess and one biliary stricture, 7% per treatment) during the follow-up, but no procedure-related deaths. RFA is safe and provides successful local tumor control in patients with recurrent ICC after curative resection. RFA for recurrent ICC resulted in a median overall survival rate of 27.4 months after RFA in the present series.European journal of radiology 10/2010; 80(3):e221-5. DOI:10.1016/j.ejrad.2010.09.019 · 2.16 Impact Factor
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ABSTRACT: This paper proposes a novel multiple access control (MAC) protocol, User-dependent Perfect-scheduling Multiple Access (UPMA) protocol, which supports joint transmission of voice and data packets. With the self-organizing algorithm, the exact number of mobile terminals (MT) in active state can be determined. Thus the transmission of MT can be perfectly scheduled by means of polling. Meanwhile, the unique frame structure of the UPMA protocol guarantees that the voice traffic is always transmitted prior to the data traffic. Furthermore, an effective collision resolution algorithm is proposed to guarantee rapid channel access for activated MT. Finally, performance of the UPMA protocol is evaluated by simulation and compared with the MPRMA protocol. Simulation results show that the UPMA protocol has better performance.Vehicular Technology Conference, 2002. VTC Spring 2002. IEEE 55th; 02/2002