Article

Refractive Index, Viscosity, and Solubility at 30 °C, and Density at 25 °C for the System Fructose + Glucose + Ethanol + Water

Suranaree University of Technology, Khorat, Nakhon Ratchasima, Thailand
Journal of Chemical & Engineering Data (Impact Factor: 2.05). 08/2000; 45(5). DOI: 10.1021/je000080m

ABSTRACT Commercial crystalline fructose is currently prepared by chromatographic separation of aqueous solutions of fructose and glucose followed by crystallization in either aqueous or aqueous−ethanol solutions. It may be possible to use one or more crystallization steps instead of the chromatographic process, thus producing crystalline product more directly. In this study the solubility, refractive index, and viscosity of solutions of fructose + glucose + ethanol + water were measured at 30 °C, and the densities of solutions with solvent concentrations of 40, 60, and 80 mass % ethanol were measured at 25 °C. These properties will be useful for crystallization studies for this system.

0 Followers
 · 
207 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: The solubilities of (2R,3S,4R)-2,3,4,5-tetrahydroxypentanal (xylose), (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal hydrate (maltose monohydrate), (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol dihydrate (trehalose dihydrate), and (3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol (mannose) in the mixtures of ethanol and water from (278.2 to 298.2) K were determined. The solubilities of all the four saccharides in ethanol–water mixtures increased as equilibrium temperature increased. The solubilities of trehalose dihydrate, xylose, and mannose decreased as ethanol mass fraction in the mixed solvent increased. Maltose monohydrate solubility decreased when ethanol mass fraction in the mixed solvent was less than 0.9. The solubilities of xylose and mannose were predicted with A-UNIFAC, and the average relative deviations (ARD) values were less than 22 %. The solubilities of maltose monohydrate and trehalose dihydrate were calculated with the modified UNIQUAC model. New interaction parameters were calibrated. The ARD values for trehalose dihydrate solubility and maltose monohydrate solubility are 28.6 % and 17.9 %, respectively.
    Journal of Chemical & Engineering Data 10/2012; 57(11):3264–3269. DOI:10.1021/je300885g · 2.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ethanol precipitation is an important purification process affecting the safety and efficacy of botanical injections. In this paper, the second ethanol precipitation of Guanxinning injection was optimized with response surface methodology as a sample to represent the principles of indicator selection. The influences of three factors, including dry matter content of concentrated supernatant (DMCCS), refrigeration temperature, and the mass ratio of ethanol and concentrated supernatant (E/CS ratio) were explained based on the precipitation mechanism. To characterize the effects of ethanol precipitation on drug safety, drug efficacy, and drug quality control, phenolic compound recovery and dry matter removal were selected as optimization criteria. In the optimization, E/CS ratio was set to 3.60. The optimum operating conditions were found at refrigeration temperature of 18.66°C and DMCCS of 0.58. Most of the experimental results at optimum operating conditions agreed well with the predicted results.
    Separation Science and Technology 02/2014; 49(4). DOI:10.1080/01496395.2013.840000 · 1.20 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The solubilities of d-glucose, d-arabinose, d-xylose, d-fructose, d-mannose, and sucrose in methanol and methanol–water mixtures (<25 wt % water) were determined at temperatures between 295 and 353 K using a unique high-throughput screening technique. The data were modeled with a UNIQUAC framework with an average error between calculated and experimental data of 3.7%. The results provide input for the design of efficient chemical processes for the conversion of these sugars into valuable biobased building blocks in methanol–water mixtures.
    Industrial & Engineering Chemistry Research 04/2014; 53(19):8285–8290. DOI:10.1021/ie500576q · 2.24 Impact Factor