A case report of successful pregnancy in a patient with pure 46,XY gonadal dysgenesis
ABSTRACT To report a successful pregnancy in a patient with pure 46,XY gonadal dysgenesis.
Academic reproductive endocrinology and infertility unit.
A patient with pure 46,XY gonadal dysgenesis and a desire to become pregnant.
Laparoscopic gonadectomy, in vitro fertilization using donor oocytes, transfer of cryopreserved blastocysts, and cesarean delivery.
Successful pregnancy and live birth.
Successful pregnancy and delivery of a healthy infant following in vitro fertilization using donor oocytes and embryo transfer.
With the use of donor oocytes, patients with pure 46,XY gonadal dysgenesis can anticipate successful pregnancy.
Journal of Obstetrics and Gynaecology 10/2013; 33(7):739. DOI:10.3109/01443615.2013.810200 · 0.60 Impact Factor
Journal of Obstetrics and Gynaecology 10/2013; 33(7):737-738. DOI:10.3109/01443615.2013.822480 · 0.60 Impact Factor
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ABSTRACT: Swyer syndrome or pure 46, XY gonadal dysgenesis is a condition in which the individuals have female appearance. They classically present as sexually infantile phenotypic females with primary amenorrhoea. People with this disorder have female external genitalia but the uterus and fallopian tubes are underdeveloped. However, they do not have functional gonads (ovaries or testes). Instead, they have streak gonads. We are reporting a case of Swyer syndrome with partially developed breasts, hypoplastic uterus, and absent streak gonads. The patient was treated with hormonal therapy and few years after her presentation, breast and uterine development were noted. In view that the patient is already married, the option of fertility was discussed with her. This case illustrates a rare case of gonadal dysgenesis and demonstrates the importance of counseling on the options of treatment, especially regarding fertility.Malaysian Family Physician 10/2013; 8(2):58-61.