A case report of successful pregnancy in a patient with pure 46,XY gonadal dysgenesis
ABSTRACT To report a successful pregnancy in a patient with pure 46,XY gonadal dysgenesis.
Academic reproductive endocrinology and infertility unit.
A patient with pure 46,XY gonadal dysgenesis and a desire to become pregnant.
Laparoscopic gonadectomy, in vitro fertilization using donor oocytes, transfer of cryopreserved blastocysts, and cesarean delivery.
Successful pregnancy and live birth.
Successful pregnancy and delivery of a healthy infant following in vitro fertilization using donor oocytes and embryo transfer.
With the use of donor oocytes, patients with pure 46,XY gonadal dysgenesis can anticipate successful pregnancy.
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ABSTRACT: To report a rare presentation of Swyer syndrome in a woman with pure 46,XY gonadal dysgenesis. Case report. Academic gynecology and obstetrics department. A 28-year-old woman with primary amenorrhea. Laparoscopic gonadectomy. Age at diagnosis, risk of gonadal malignancy, bone mineral density, uterus size, height. The patient had pure 46,XY gonadal dysgenesis with hypoplastic uterus, which is a rare finding in Swyer syndrome. She had developed no gonadal malignancies and, despite receiving estrogen, had remained amenorrheic. Further studies should be done on this rare chromosomal condition to find the exact factors affecting the uterus size and to improve the ways of inducing puberty in such patients by considering the age of diagnosis in order to help them have a normal sex life and also the ability to carry a fetus in their immature uteruses.Fertility and sterility 11/2009; 93(1):267.e13-4. DOI:10.1016/j.fertnstert.2009.09.062 · 4.30 Impact Factor