Article

Intentional weight loss and mortality among initially healthy men and women

Research Unit for Dietary Studies, Institute of Preventive Medicine, Center for Health and Society, Copenhagen, Denmark.
Nutrition Reviews (Impact Factor: 5.54). 08/2008; 66(7):375-86. DOI: 10.1111/j.1753-4887.2008.00047.x
Source: PubMed

ABSTRACT Most prospective observational studies suggest that weight loss increases the risk of premature death among obese individuals. This is surprising because clinical studies show that weight loss generally leads to overall improvements in cardiovascular risk factors. It is sometimes argued that the increased mortality observed with weight loss must depend on confounding or poor study designs. This review was conducted to summarize results from studies on intentional weight loss and mortality among healthy individuals, while carefully considering the designs and problems in these studies. Evaluation criteria with a rating scale were developed. Of the studies evaluated, two found decreased mortality with intentional weight loss, three found increased mortality, and four found no significant associations between intentional weight loss and total mortality. Thus, it is still not possible for health authorities to make secure recommendations on intentional weight loss. More studies designed to specifically address this issue are warranted.

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    • "e l s e v i e r . c o m / l o c a t e / y g y n o individuals is now also beginning to emerge [14]. In a recent review Wolin et al. suggested that obesity causes a substantial proportion of all cancers, and emerging evidence suggests that adult weight loss reduces cancer risk [5]. "
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    • "os basados en ocho estudios, publicados de 1993 al 2005. Los resultados más importantes son las diferencias en la mortalidad dependiendo del género, de la enfermedad coexistente y de la intencionalidad de la pérdida de peso. En mujeres y en las personas con sobrepeso y diabetes, disminuyó el riesgo de mortalidad por la pérdida de peso intencional. Simonsen y cols. (2008) 25 , realizaron una revision de estudios prospectivos publicados de 1995 al 2005, en la que analizaron la asociación de la pérdida de peso intencional sobre la mortalidad en individuos sanos. Desarrollaron un instrumento para evaluar la calidad metodológica de los estudios, en el cual tomaron en cuenta 10 criterios seleccionados por los"
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