Emergency department noninvasive (NICOM) cardiac outputs are associated with trauma activation, patient injury severity and host conditions and mortality
ABSTRACT Anoninvasive cardiac output (CO) monitor (NICOM), using Bioreactance technology, has been validated in several nontrauma patient studies. We hypothesized that NICOM CO would have more significant associations with clinical conditions than would systolic blood pressure (sBP).
This is a prospective observational study of consecutive trauma activation patients during the first 10 to 60 minutes after emergency department arrival.
Analysis includes 270 consecutive trauma activation patients with 1,568 observations. CO was decreased (p ≤ 0.002) with major blood loss, hypotension, red blood cell transfusion, Injury Severity Score (ISS) higher than 20, low PetCO₂, abnormal pupils, elderly, preexisting conditions, low body surface area level, females, hypothermia, and death. CO was increased (p < 0.0001) with base deficit, ethanol positivity, and illicit drug positivity. The sBP was decreased (p ≤ 0.0005) with major blood loss, red blood cell transfusion, low PetCO₂, low body surface area level, and illicit drug positivity. The sBP was increased (p e 0.01) with ISS higher than 20, elderly, and preexisting conditions. Total significant condition associations were CO 83% (15 of 18 patients) and sBP 47% (8 of 17 patients; p = 0.03). In hypotensive patients, CO was lower with major blood loss (3.3 ± 2.1 L/ min) than without (6.0 ± 2.2 L/min; p < 0.0001). Of survivors with ISS 15 or higher, NICOM patients experienced a shorter hospital length of stay (10.5 days) when compared with 2009 and 2010 patients (14.0 days; p = 0.03).
The multiple associations of CO with patient conditions imply that NICOM provides an objective and clinically valid, relevant, and discriminate measure of cardiac function in acutely injured trauma activation patients. NICOM use may be associated with a shorter length of stay in surviving patients with complex injuries.
- Critical Care 03/2013; 17(2). DOI:10.1186/cc12139 · 5.04 Impact Factor
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ABSTRACT: In a smaller experience, the authors previously demonstrated that end-tidal carbon dioxide (PetCO2) and cardiac output (CO) had a positive association in emergently intubated trauma patients during Emergency Department resuscitation. The aim of this larger study was to reassess the relationship of PetCO2 with CO and identify patient risk-conditions influencing PetCO2 and CO values. The investigation consists of acutely injured trauma patients requiring emergency tracheal intubation. The study focuses on the prospective collection of PetCO2 and noninvasive CO monitor (NICOM(R)) values in the Emergency Department. From the end of March through August 2011, 73 patients had 318 pairs of PetCO2 (mm Hg) and CO (L/min.) values. Mean data included Injury Severity Score (ISS) >=15 in 65.2%, Glasgow Coma Score of 6.4 +/- 4.6, hypotension in 19.0%, and death in 34.3%. With PetCO2 <= 25 (15.9 +/- 8.0), systolic blood pressure was 77.0 +/- 69, CO was 3.2 +/- 3.0, cardiac arrest was 60.4%, and mortality was 84.9%. During hypotension, CO was lower with major blood loss (1.9), than without major loss (5.0; P = 0.0008). Low PetCO2 was associated with low CO (P < 0.0001). Low PetCO2 was associated (P <= 0.0012) with ISS > 20, hypotension, bradycardia, major blood loss, abnormal pupils, cardiac arrest, and death. Low CO was associated (P <= 0.0059) with ISS > 20, hypotension, bradycardia, major blood loss, abnormal pupils, cardiac arrest, and death. During emergency department resuscitation, a decline in PetCO2 correlates with decreases in noninvasive CO in emergently intubated trauma patients. Decreasing PetCO2 and declining NICOM CO are associated with hemodynamic instability, hemorrhage, abnormal pupils (this is in harmony with Dr. Johnson's critique and the revised title), and death. The study indicates that NICOM CO values are clinically discriminate and have physiologic validity.BMC Anesthesiology 09/2013; 13(1):20. DOI:10.1186/1471-2253-13-20 · 1.33 Impact Factor
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ABSTRACT: Intravenous perfluorocarbons (PFC) have reduced the effects of decompression sickness (DCS) and improved mortality rates in animal models. However, concerns for the physiologic effects of DCS combined with PFC therapy have not been examined in a balanced mixed gender population. Methods: Thirty-two (16 male, 16 female) instrumented and sedated juvenile Yorkshire swine were exposed to 200 fsw for 31 minutes of hyperbaric air. Pulmonary artery pressure (PAP), cardiac output (CO) and systemic arterial pressure (SAP) were monitored before (control) and after exposure. Animals were randomized to treatment with Oxycyte (5cc/kg) vs saline (control) with 100% oxygen administered upon DCS onset; animals were observed for 90 minutes. Parameters recorded and analyzed included PAP, CO, SAP. Results: In all animals PAP began to rise prior cutis marmorata (CM) onset, the first sign of clinical DCS, generally peaking after CM onset. Female swine, compared to castrated males, had a more rapid onset of CM (7.30 vs. 11.46 min post-surfacing) and earlier onset to maximal PAP (6.41 vs. 9.69 min post-CM onset). Oxycyte therapy was associated with a sustained PAP elevation above controls in both genders (33.41 vs. 25.78 mm Hg). Significant pattern differences in PAP, CO and SAP were noted between genders and between therapeutic groups. There were no statistically significant differences in survival or paralysis between the PFC and control groups during the 48 hr observation period. Conclusions: Oxycyte therapy for DCS is associated with a prolonged PAP increase in swine. These species and gender differences warrant further exploration.Journal of Applied Physiology 10/2014; 118(1):jap.00727.2014. DOI:10.1152/japplphysiol.00727.2014 · 3.43 Impact Factor