Human Parechovirus in Respiratory Specimens from Children in Kansas City, Missouri
ABSTRACT We detected a 3% prevalence rate for human parechovirus (HPeV) in 720 respiratory specimens collected from 637 children seen in our hospital in 2009. Fifteen of 20 were HPeV-3 and two were HPeV-1. Only nonspecific, modest respiratory symptoms were evident in patients with detectable HPeV in respiratory specimens. Seven patients had concurrent respiratory and CNS HPeV-3 infection suggesting a possible respiratory route of acquisition.
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ABSTRACT: Sepsis and sepsis-like illness in neonates and infants are serious emergencies. Recently, human parecho-virus type 3 (HPeV-3) has been identified as a further etiologic agent for these conditions. We report two unlinked cases of infant HPeV-3 sepsis-like illness whose sources could be traced back to elder siblings with mild gastroenteritis and respiratory symptoms.Journal of clinical microbiology 12/2012; 51(2). DOI:10.1128/JCM.02731-12 · 4.23 Impact Factor
Article: The particulars on parechovirus.
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ABSTRACT: Background: The symptoms observed in children with human parechovirus (HPeV) infection vary widely from asymptomatic or mild gastrointestinal infections to more severe central nervous system infections and sepsis-like disease. Many of the disease associations are, however, only suggestive. In this study, we examined the connection between HPeV and acute otitis media, lower respiratory infections and suspected central nervous system infections. Methods: An HPeV specific real-time reverese transcriptase polymerase chain reaction was used to detect HPeV RNA. We analyzed altogether 200 middle-ear fluid samples, 192 nasopharyngeal aspirates, 79 cerebrospinal fluid specimens and 50 serum and 5 fecal or fecal culture samples. Positive samples were typed by sequencing the VP1 region. Results: Seven (8%) of 85 children with suspected central nervous system infections were positive for HPeV. Of these, 4 (all in autumn 2012 and from children <3 months of age) were typed to be HPeV4, whereas 1 child had HPeV3. HPeV4 was detected from stool, serum and cerebrospinal fluid. The children with acute otitis media tested HPeV positive in 2.5% episodes. In the lower respiratory cases, HPeV was absent. Conclusions: The findings reported in this study suggest that HPeV4 can cause sepsis-like disease in young infants and be present in cerebrospinal fluid. Furthermore, this report shows that HPeV findings in children with more severe symptoms occur also in Finland.The Pediatric Infectious Disease Journal 11/2014; 33(11):1109-13. DOI:10.1097/INF.0000000000000401 · 3.14 Impact Factor