Complement-Targeted Therapeutics in Periodontitis

Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA, .
Advances in Experimental Medicine and Biology (Impact Factor: 1.96). 02/2013; 734:197-206. DOI: 10.1007/978-1-4614-4118-2_13
Source: PubMed

ABSTRACT Periodontitis is a prevalent oral chronic inflammatory disease which, in severe forms, may exert a major impact on systemic health. Clinical and histological observations, as well as experimental animal studies, suggest involvement of the complement system in periodontitis. However, the precise roles of the various complement components and pathways in periodontitis have only recently started to be elucidated. In this chapter, we review recent progress in the field and discuss the potential of complement-targeted therapeutics in the treatment of periodontitis.

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