Dietary patterns are associated with plasma F(2)-isoprostanes in an observational cohort study of adults.
ABSTRACT Associations between individual foods or nutrients and oxidative markers have been reported. Comprehensive measures of food intake may be uniquely informative, given the complexity of oxidative systems and the possibility of antioxidant synergies. We quantified associations over a 20-year history between three food-based dietary patterns, summary measures of whole diet, and a plasma biomarker of lipid peroxidation, F(2)-isoprostanes, in a cohort of Americans ages 18-30 at year 0 (1985-1986). We assessed diet at years 0, 7, and 20 through a detailed history of past-month food consumption and supplement use and measured plasma F(2)-isoprostanes at years 15 and 20. We created three different dietary patterns: (1) a priori ("a priori diet quality score") based on hypothesized healthy foods, (2) an empirical pattern reflecting high fruit and vegetable intake ("fruit-veg"), and (3) an empirical pattern reflecting high meat intake ("meat"). We used linear regression to estimate associations between each dietary pattern and plasma F(2)-isoprostanes cross-sectionally (at year 20, n=2736) and prospectively (year 0/7 average diet and year 15/20 average F(2)-isoprostanes, n=2718), adjusting for age, sex, race, total energy intake, education, smoking, body mass index, waist circumference, physical activity, and supplement use. In multivariable-adjusted cross-sectional analysis, the a priori diet quality score and the fruit-veg diet pattern were negatively, and the meat pattern was positively, associated with F(2)-isoprostanes (all p values <0.001). These associations remained statistically significant in prospective analysis. Our findings suggest that a long-term adherence to a diet rich in fruits and vegetables and low in red meat may decrease lipid peroxidation.
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ABSTRACT: Preserving cognitive function is an important public health issue. We investigated whether dietary pattern associates with cognitive function in middle-age. We studied 2435 participants in the community-based Coronary Artery Risk Development in Young Adults (CARDIA) study of black and white men and women aged 18-30 in 1985-86 (year 0, Y0). We hypothesized that a higher A Priori Diet Quality Score, measured at Y0 and Y20, is associated with better cognitive function measured at Y25. The diet score incorporated 46 food groups (each in servings/day) as the sum of quintile ranks of food groups rated beneficial, 0 for food groups rated neutral, and reversed quintile ranks for food groups rated adverse; higher score indicated better diet quality. Y25 cognitive testing included verbal memory (Rey Auditory-Verbal Learning Test (RAVLT)), psychomotor speed (Digit Symbol Substitution Test (DSST)) and executive function (Stroop). Per 10-unit higher diet score at Y20, the RAVLT was 0.32 words recalled higher, the DSST was 1.76 digits higher, and the Stroop was 1.00 seconds+errors lower (better performance) after adjusting for race, sex, age, clinic, and energy intake. Further adjustment for physical activity, smoking, education, and body mass index attenuated the association slightly. Diet score at Y0 and increase in diet score over 20 years were also positively associated with each cognitive test. A higher quality dietary pattern was associated with better cognitive function 5 years and even 25 years later in apparently healthy middle-aged adults.The Journal of Nutrition Health and Aging 01/2015; 19(1):33-8. DOI:10.1007/s12603-014-0491-7 · 2.66 Impact Factor
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ABSTRACT: Context: Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures. Objective: To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers. Methods: In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models. Results: Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated. Conclusions: Different biomarkers of oxidative stress may reflect different biological processes.Biomarkers 07/2014; 19(6). DOI:10.3109/1354750X.2014.937361 · 2.52 Impact Factor
Article: The isoprostanes—25 years later[Show abstract] [Hide abstract]
ABSTRACT: Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first isoprostane species discovered were isomeric to prostaglandin F2α and were thus termed F2-IsoPs. Since the initial discovery of the F2-IsoPs, IsoPs with differing ring structures have been identified as well as IsoPs from different polyunsaturated fatty acids, including eicosapentaenoic acid and docosahexanenoic acid. The discovery of these molecules in vivo in humans has been a major contribution to the field of lipid oxidation and free radical research over the course of the past 25 years. These molecules have been determined to be both biomarkers and mediators of oxidative stress in numerous disease settings. This review focuses on recent developments in the field with an emphasis on clinical research. Special focus is given to the use of IsoPs as biomarkers in obesity, ischemia-reperfusion injury, the central nervous system, cancer, and genetic disorders. Additionally, attention is paid to diet and lifestyle factors that can affect endogenous levels of IsoPs. This article is part of a Special Issue entitled “Oxygenated metabolism of PUFA: Analysis and biological relevance.”Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 10/2014; 1851(4). DOI:10.1016/j.bbalip.2014.10.007 · 4.50 Impact Factor
Katie A Meyer