Does ovarian endometrioma affect the number of oocytes retrieved for in vitro fertilization?

Bratislavske lekarske listy (Impact Factor: 0.44). 09/2012; 113(9):544-7. DOI: 10.4149/BLL_2012_122
Source: PubMed


Objective: To investigate the effects of ovarian endometrioma on the number of oocytes retrieved for in vitro fertilization (IVF).Background: The presence of endometrioma may be the most important predictor of a poor reproductive outcome. Literature data suggest that ovarian endometriomas might affect the response to ovarian stimulation and oocyte retrieval.Methods: The present retrospective study evaluates 2,023 women who applied to our center with an infertility complaint. Twenty-nine women with endometriomas (group 1) who were treated with IVF were included in the study. They were compared with 51 women with unexplained infertility (group 2) regarding the number of retrieved oocytes after egg retrieval and number of metaphase II oocytes. The diagnosis of endometrioma was made via ultrasound examination with the identification of low-density cystic masses in the ovaries. The patients underwent a controlled ovarian hyperstimulation (COH) with either the long agonist mini-dose protocol or the multi-dose antagonist protocol.Results: The incidence of endometrioma in infertile women was found to be 1.4 %. The women's ages ranged between 24 and 45 years, and the duration of their infertility ranged between 12 and 216 months. The endometrioma was bilateral in 24 % of the cases. The mean endometrioma diameter was 26.2±7.3 mm for the right ovary and 23.2±6.1 mm for the left ovary. The average number of retrieved oocytes after egg retrieval in groups 1 and 2 was 12.4±8.3 and 12.2±8.6, respectively. The average number of metaphase II oocytes in groups 1 and 2 was 8.6±6.1 and 9.4±7.3, respectively. The number of retrieved oocytes after egg retrieval and the number of metaphase II oocytes in both endometrioma group and unexplained infertile group were similar (p >0.05).Conclusion: Endometrioma did not reduce the number of retrieved oocytes in a COH cycle for IVF treatment. However it should be noted that the ovarian response is affected by the size of endometriomas, bilaterality, previous surgeries, recurrence, and the patient's age (Tab. 1, Ref. 31). Keywords: endometrioma, oocyte, infertility.

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    • "Color versions of one or more of the figures in the article can be found online. number of oocytes retrieved during in vitro fertilization (IVF) cycles, but characteristics such as the size of endometriomas, bilaterality, and previous excision surgeries, may affect the ovarian response and oocyte quality [Kiran et al. 2012]. "
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    ABSTRACT: Endometriosis is a chronic gynecological condition that affects 10-32% of women of reproductive age and may lead to infertility. The study of protein profiles in follicular fluid may assist in elucidating possible biomarkers related to this disease. For this, follicular fluid samples were obtained from women with tubal factor or minimal male factor infertility who had pregnancy outcomes after in vitro fertilization (IVF) treatment (control group, n ¼ 10), women with endometriosis (endometriosis group, n ¼ 10), along with the endometrioma from these same patients were included (endometrioma group, n ¼ 10). For proteomic analysis, samples were pooled according to their respective groups and normalized to protein content. Proteins were analyzed by in tandem mass spectrometry (MS E) Spectra processing and the ProteinLynx Global Server v.2.5. was used for database searching. Data was submitted to the biological network analysis using Cytoscape 2.8.2 with ClueGO plugin. As a result, 535 proteins were identified among all groups. The control group differentially or uniquely expressed 33 (6%) proteins and equal expression of 98 (18%) proteins was observed in the control and endometriosis groups of which 41 (7%) proteins were further identified and/or quantified. Six (1%) proteins were observed in both the endometriosis and endometrioma groups, but 212 (39%) proteins were exclusively identified and/or quantified in the endometrioma group. There were 9 (1%) proteins observed in both the control and endometrioma groups and there were 139 (25%) proteins common among all three groups. Distinct differences among the protein profiles in the follicular fluid of patients included in this study were found, identifying proteins related to the disease progression and IVF success. Thus, some pathways related to endometriosis are associated with the presence of specific proteins, as well as the absence of others. This study provides a first step to the development of more sensitive diagnostic tests and treatment. Abbreviations: bhCG: beta subunit of human chorionic gonadotropin; FSH: follicle stimulating hormone; FF: follicular fluid; GO: Gene Ontology; GnRH: gonadotropin-releasing hormone; hCG: human chorionic gonadotropins; ICSI: intracytoplasmic sperm injection; IVF: in vitro fertilization; KEGG: Kyoto Encyclopedia of Genes and Genomes; LH: luteinizing hormone; MS: mass spectrometry; MS E : in tandem mass spectrometry; nanoESI MSE: nano Electrospray MSE; nanoUPLCtandem-: nano Ultra Performance Liquid Chromatography tamdem; ROS: reactive oxygen species; VDBP: vitamin D-binding protein
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    ABSTRACT: Endometriosis is a complex disease of young women in reproductive age. It's responsible for dysmenorrhea, dyspareunia, chronic pelvic pain and infertility. Medical and surgical treatments have different aims. Hormonal suppression tends to stop natural evolution of the disease and surgery enables macroscopic excisions of endometriotic implants. Outcomes depend on the stage and the preoperative symptoms. This article summarizes a review of surgical management of endometriosis describing surgical indications, techniques, and outcomes in terms of pain and fertility.
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