A structural model for virulence organellae of gram-negative organisms with reference to Salmonella pathogenicity in chicken ileum.
Full-textDOI: · Available from: Rakesh Yashroy, Jul 03, 2015
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ABSTRACT: Ultrastructual studies of experimentally infected chicken (n=5) ileum reveal that virulent Salmonella (3,10:r:-) signal their own phagocytosis by tissue macrophages, and are able to dodge host defence mechanisms. The observed fusion of membrane vesicles (MVs) liberated from virulent organisms with closely interacting macrophages is proposed here to constitute a mechanism of type III secretion-like system of gram-negative organisms in general, in order to translocate the necessary biochemical signals into the cytosol of macrophages (eukaryotic host cells). This leads to (1) membrane ruffling culminating in augmented phagocytosis of salmonellae, (2) inhibition of phagosome-lysosome (P-L) fusion for survival and replication of pathogens within the host cytoplasm and (3) initiation of apoptosis of the infected macrophages and ultimate release of replicated salmonellae from the migrating host cells.The Journal of Poultry Science 01/2000; 35(3):276-281. · 0.79 Impact Factor
- Poultry Production under Stress, 1st edited by R.P. Moudgal, Jag Mohan, Rajvir Singh, 01/2000: pages 292-300; Central Avian Research Institute, Bareilly, UP, India.
Conference Paper: Host-pathogen interface: Ultrastructure of Salmonella virulence.XXIV annual conference on Electron Microscopy and allied fields; 02/2001
Questions & Answers about this publication
- Why lipopolysaccharide outer membrane of gram-negative microbes is so pliable, extendable and pinchable as vesicles vide reference here? All gram negative microbes have a characteristic lipopolysaccharide-rich outer membrane covering. Is it biophysically better than the lipid-bilayer structure common to all other cell membranes?Following