Impact of Age, Phenotype and Cardio-Renal Function on Plasma C-Type and B-Type Natriuretic Peptide Forms in an Adult Population.

Department of Medicine, University of Otago, Christchurch, New Zealand.
Clinical Endocrinology (Impact Factor: 3.35). 09/2012; 78(5). DOI: 10.1111/cen.12035
Source: PubMed

ABSTRACT CONTEXT: In contrast to the cardiac hormones, Atrial Natriuretic Peptide (ANP) and B-type Natriuretic Peptide (BNP), variations in plasma concentrations of C-type Natriuretic Peptide (CNP) in healthy adults are ill-defined, limiting their clinical application. OBJECTIVE: Our objective was to define the effect of age, phenotype (gender, height, BMI), and cardiac and renal function on plasma CNP peptides in an adults population without renal or cardiovascular disease. DESIGN AND SETTING: This was a prospective cross sectional observational study of adult volunteers, aged 21-80yr, randomly selected from the electoral roll. SUBJECTS AND METHODS: Plasma CNP and its associated aminoterminal propeptide (NTproCNP) were measured in 258 subjects and related to age, gender, height and plasma creatinine. Sub group analyses seeking associations with cardiac function (plasma BNP and NTproBNP) and bone turnover (bALP) were also determined. RESULTS: Plasma concentrations of CNP peptides in men continued to decline from adolescent values to reach a nadir in the 5(th) decade after which values increased. Similar but less marked changes occurred in women. In both sexes, NTproCNP was inversely and independently correlated with height. In contrast to BNP peptides, NTproCNP was higher in men, significantly related to creatinine and positively related to bALP. CONCLUSIONS: Gender and age specific changes affect CNP peptides in adults. Inverse associations of NTproCNP with adult height, positive correlation with creatinine - and in contrast to CNP - no association with BNP are further unique findings distinguishing NTproCNP which need to be considered in future studies. © 2012 Blackwell Publishing Ltd.

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