Lessons learned from Trypanosoma cruzi test implementation

e-mail: , Community Blood Center of Greater Kansas City, Kansas City, MO Canadian Blood Services, Ottawa, Ontario, Canada.
Transfusion (Impact Factor: 3.23). 09/2012; 52(9):1849-51. DOI: 10.1111/j.1537-2995.2012.03806.x
Source: PubMed
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    ABSTRACT: An emerging infection is defined as one that has appeared in a population for the first time, or that may have existed previously but is rapidly increasing in incidence or geographic range. The Asia Pacific region, with 30% of global population, has a reputation as a hot spot for emerging infections. The emergence of severe acute respiratory syndrome exactly 10 years ago dramatically transformed individual and national awareness and capabilities for identifying and responding to regional emerging infectious threats. The impact of emerging infections on the blood supply may be direct through the potential for transmission through transfusion, the effect on blood donor attendance and eligibility and the effect on blood demand. There is a need for constant surveillance and the capacity to identify, assess and manage risks to the blood supply. In recent years, the strengthening of regional and international partnerships and the development of new risk assessment tools has improved our ability to respond to infectious threats. Nonetheless, the volatile and ever-changing nature of emerging infections will remain a constant challenge to the vigilance and response capabilities of the transfusion medicine community.
    ISBT Science Series 07/2013; 9(1). DOI:10.1111/voxs.12064
  • Transfusion 03/2014; 54(3):745-6. DOI:10.1111/trf.12505 · 3.23 Impact Factor
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    ABSTRACT: Background Trypanosoma cruzi is the causal agent of Chagas disease. Of the Mexican states, Veracruz is among the most affected by this sickness. However, the actual epidemiologic situation of this disease is not well understood. This study sought to determine the prevalence and risk factors for Chagas disease among Veracruzan blood donors.Study Design and Methods Blood donors from Centro Estatal de la Transfusion Sanguinea de Veracruz were included. Blood units were serologically scrutinized for T. cruzi antibodies using enzyme-linked immunosorbent assays. To identify risk factors, demographic data were collected from the medical records of positive donors and a representative sample of healthy donors.ResultsA total of 87,232 donations were analyzed, and the mean prevalence of T. cruzi was found to be 0.5%. The identified risk factors were living as a couple and in a rural area, having a low level of education, being a farmer, dwelling in a house with earthen or wooden walls and a tile or thatch roof, living with domestic animals, recognition of or exposure to triatomine bugs, and residing in the Huasteca region. An increase of rural-living donors infected with T. cruzi was observed in the past 3 years of the study period.Conclusion The prevalence to Chagas disease has not decreased in the past decade and the disease appears to be spreading in rural areas of Veracruz. This increases the risk of T. cruzi transfusion-transmitted infection, not only in Veracruz and Mexico, but also in other nonendemic countries that receive immigrants from Veracruz State.
    Transfusion 10/2014; 55(3). DOI:10.1111/trf.12860 · 3.23 Impact Factor