Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity.

Inst. Pharmacology and Toxicology, Otto-von-Guericke University, Magdeburg, Germany.
Phytomedicine: international journal of phytotherapy and phytopharmacology (Impact Factor: 2.97). 08/2012; 19(13):1216-22. DOI: 10.1016/j.phymed.2012.08.003
Source: PubMed

ABSTRACT Valerian is one of the most commonly used herbal remedies for the treatment of insomnia and anxiety. Valerian extracts allosterically modulate GABAA receptors, an action related to valerenic acid, which is one of the active compounds determined from pharmacological studies. Derivatives of valerenic acid, i.e. acetoxy valerenic acid or hydroxy valerenic acid, do not allosterically modulate GABAA receptors, but they bind to identical binding sites. Therefore, the question arises whether they might interfere with the effects of valerenic acid. Two valerian extracts were tested in the elevated plus maze test and the tail suspension test for anxiolytic and antidepressive activity, respectively. Reference substances were diazepam (1.0mg/kg) and imipramine (30mg/kg). The extracts were standardized to the identical total amounts of the acids (0.1; 0.5; 1.0 and 2.0mg/kg), i.e. valerenic and acetoxy valerenic acid, but the ratio between the acids was different (12:1 and 1:1.5). The extract with the ratio 12:1 prolonged the time spent on the open arm significantly when 0.5mg/kg was applied. Of the other extract, with the ratio 1:1.5, four times that amount was required (2.0mg/kg). Both of the tested extracts did not show any antidepressive effect, rather the other way around, the extract with the ratio 1:1.5 prolonged the immobility phase. However, since the core body temperature was reduced by the 1.0 and 2.0mg/kg extract dose, the prolongation may be related to the temperature phenomenon and is not indicative of a specific depressive action. In conclusion, the anxiolytic activity of the valerian extract seems rather related to valerenic acid and, moreover, standardization with respect to the total amount of valerenic acids, i.e. valerenic acid together with acetoxy valerenic acid, is misleading.

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    ABSTRACT: The Valerian plant is known as a medicinal plant with sedative, anxiolytic, anti-inflammatory properties and somnifacient effect. Therefore studying cardiac effects of this plant can help to gain a better understanding of its pharmacodynamics effects in order to provide above properties. In this research 18 healthy female pet cats, 2 years old in the mean, were selected. Cardiac function indexes including the fractional shortening, ejection fraction and normal stroke volume were measured using echocardiography. Cats were fed by 500 mg/kg Valerian root extract and clinical signs like distraction and incoordination were observed after 15 minutes; the factors were measured. Results were analyzed by the statistical method of independent T-test. Obtained data was showed satisfactory results which are detailed described in the text below. The results showed that stroke volume index increased significantly while fractional shortening index decreased significantly. Also the ejection fraction index was not significant statistically. Therefore extract of the Valerian root decreases the sympathetic performance, effects on the heart indirectly, relaxes the myocardium in result of the decrease in the fractional shortening of the heart muscle and consequently increases the diastolic and systolic volume and increases the stroke volume of the blood accompanied by the decrease in the preload and after load.


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Dec 12, 2014