Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Carbohydrate polymers 10/2012; 90(3):1362-70. DOI: 10.1016/j.carbpol.2012.07.005
Source: PubMed


Silver-loaded dressings are designed to provide the same antimicrobial activity of topical silver, with the advantages of a sustained silver release and a reduced number of dressing changes. Moreover, such type of dressing must provide a moist environment, avoiding fiber shedding, dehydration and adherence to the wound site. Here we describe the preparation of a novel silver-loaded dressing based on a Gellan/Hyaff(®) (Ge-H) non woven, treated with a polyvinyl alcohol (PVA)/borax system capable to enhance the entrapment of silver in the dressing and to modulate its release. The new hydrophilic non woven dressings show enhanced water uptake capability and slow dehydration rates. A sustained silver release is also achieved. The antibacterial activity was confirmed on Staphylococcus aureus and Pseudomonas aeruginosa.

1 Follower
19 Reads
  • Source
    • "No haemolytic effect was observed. Cencetti et al., 2012 examined antimicrobial wound dressings designed for slow silver release. Nonwoven gellan-Hyaff 1 (benzyl derivative of hyaluronic acid) patches were used as a matrix. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Over the past few decades, microbial polysaccharides have been under intense investigation due to their advantageous physicochemical properties. A great structural diversity of these biomolecules has led to multiple applications in food industry, personal care products, pharmacy and medicine. Currently, one of the most widely studied and fully described member of this group is gellan. It is a linear polymer produced by Sphingomonas elodea. A polymer chain of gellan consists of a tetrasaccharide repeating unit of l-rhamnose, d-glucose and d-glucuronate. So far most of the studies have been focused on the application of gellan as a food ingredient. However, due to the unique structure and beneficial properties, gellan is currently described as a potent multifunctional additive for various pharmaceutical products. Specific gelling properties in different media led to the development of controlled release forms based on gellan. Various formulations have been studied including oral, ophthalmic, nasal and other. Recent reports suggest that gellan-based materials can also be used in regenerative medicine, stomatology or gene transfer technology.
    International Journal of Pharmaceutics 03/2014; 466(1-2). DOI:10.1016/j.ijpharm.2014.03.038 · 3.65 Impact Factor
  • Source
    • "Sodium alginate, widely used in food and pharmaceutical industries, has been used in a number of wound treatments, for both acute or chronic wounds, because when it comes into contact with the exudate or blood it forms a protective fibrous gel, which is hydrophilic, hemostatic, and rich in calcium [22]. Polyvinyl alcohol was used as film forming agent and has been often used in combination with other polymers for wound healing applications [23] [24] "
    [Show abstract] [Hide abstract]
    ABSTRACT: Burns are serious traumas related to skin damage, causing extreme pain and possibly death. Natural drugs such as Aloe vera and vitamin E have been demonstrated to be beneficial in formulations for wound healing. The aim of this work is to develop and evaluate polymeric films containing Aloe vera and vitamin E to treat wounds caused by burns. Polymeric films containing different quantities of sodium alginate and polyvinyl alcohol (PVA) were characterized for their mechanical properties and drug release. The polymeric films, which were produced, were thin, flexible, resistant, and suitable for application on damaged skin, such as in burn wounds. Around 30% of vitamin E acetate was released from the polymeric films within 12 hours. The in vivo experiments with tape stripping indicated an effective accumulation in the stratum corneum when compared to a commercial cream containing the same quantity of vitamin E acetate. Vitamin E acetate was found in higher quantities in the deep layers of the stratum corneum when the film formulation was applied. The results obtained show that the bioadhesive films containing vitamin E acetate and Aloe vera could be an innovative therapeutic system for the treatment of burns.
    01/2014; 2014(1-2):641590. DOI:10.1155/2014/641590
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In this work, silver/poly(vinyl alcohol), Ag/PVA, colloidal dispersions were obtained by electrochemical reduction of Ag+. The electrochemical synthesis of silver nanoparticles in aqueous solutions of 5 and 10 wt. % PVA, containing 0.1 M KNO3 and 3.9 mM AgNO3, was performed at a constant current density of 25 mA cm(-2) for a synthesis time of 10 min. The presence of silver nanoparticles was confirmed by UV-Vis spectroscopy. Cyclic voltammetry analysis and FT-IR spectroscopy indicated interactions between the silver nanoparticles and the PVA molecules. TEM analysis confirmed the spherical shape of the obtained silver nanoparticles, with a mean diameter of 15 +/- 9 nm.
    Journal of the Serbian Chemical Society 01/2013; 78(12):2087-2098. DOI:10.2298/JSC131017124S · 0.87 Impact Factor
Show more