Interciencia (Impact Factor: 0.19). 09/2010;

ABSTRACT espués de más de 500 años de iniciado el proce-so de conquista y coloni-zación, la distribución de la población en Venezuela no es resultado de un proceso azaroso. Es posible ubicar numerosos pobla-dos fundados por familias europeas, espe-cialmente españoles de origen canario, vas-co y gallego, distribuidos por gran parte del territorio nacional; poblaciones originadas a partir de descendientes de esclavos que con-tinúan ocupando las áreas geográficas don-de estaban las haciendas coloniales, lugar de trabajo de sus antepasados; mientras que la población aborigen sobreviviente fue inte-grada a la población mestiza urbana o des-plazada a lugares de difícil acceso, constitu-yendo actualmente alrededor del 2% de la población general (INE, 2001). Se afirma que la pobla-ción venezolana así distribuida es producto 0378-1844/10/09/654-07 $ 3.00/0

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Available from: Dinorah Castro de Guerra, Sep 28, 2015
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    ABSTRACT: The present Venezuelan population is the admixture product of Amerindians, Europeans and Africans, a process which was not homogeneous over the country. Blood groups, STRs and VNTRs, specifically D1S80, have been used successfully in admixture studies, but few have been made in Venezuela. This study aims to estimate the admixture components of Churuguara, Venezuela, and to evaluate the genetic relationship of this population with other Venezuelan as well as worldwide populations through principal component analysis and the study of dendrograms based on genetic distances. Gene frequencies of blood groups ABO and Rh (only anti D), of STRs VWA, F13A01, FES/FPS and VNTR D1S80 were studied in a sample of 60 individuals born in Churuguara, a Venezuelan town of admixed ancestry in the State of Falc6n. Admixture was estimated with Chakraborty's gene identity method, and Nei's standard genetic distance was used to build two dendrograms with the neighbour-joining approach, one based on the three STRs and the other based only on D1S80. Principal component analyses with the gene frequencies of these markers were also performed. The frequency of allele ABO*O was 0.788, of ABO*A was 0.187 and of RH*D was 0.74. D1S80 showed 16 different alleles with a heterozygosity of 0.880, whilst the three STRs showed only eight different alleles and heterozygosities between 0.733 and 0.797. The estimates of admixture obtained in this analysis were 52.5% for the Spanish parental group, 27.6% for the African and 19.9% for the Amerindian. Comparison of Churuguara with other Latin American populations shows that its African component is not as high as that observed in Colombian Choco, but it is higher than that observed in other samples from Colombia, Chile and Maracaibo (Venezuela). Results of the admixture analysis are consistent with those obtained with two dendrograms and principal component analyses, suggesting that the strong initial Amerindian component of 500 years ago has been diluted by the continuous flow of European genes, mainly Spanish, to this region.
    Annals of Human Biology 11/2004; 31(6):669-80. DOI:10.1080/03014460400019760 · 1.27 Impact Factor
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    ABSTRACT: Haplotype frequencies for the beta-globin gene cluster were determined in 96 chromosomes from a Venezuelan mixed population. Twelve haplotypes were observed, the most frequent of which were 2, 3, and 4; all others showed prevalences below 10%. When the results were compared with those of 13 other groups using a phylogenetic tree, they clustered in an intermediate position somewhat nearer to those of four sub-Saharan African populations. This is in accordance with historical and other genetic data which indicate an important contribution of people of African ancestry to this population. The high heterozygosity (80%) and the intermediate position in the tree, on the other hand, possibly reflect past intermixture of these African-derived individuals with Europeans and Amerindians. Am. J. Hum. Biol. 9:323–327, 1997. © 1997 Wiley-Liss, Inc.
    American Journal of Human Biology 01/1997; 9(3):323 - 327. DOI:10.1002/(SICI)1520-6300(1997)9:3<323::AID-AJHB5>3.0.CO;2-Z · 1.70 Impact Factor
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    ABSTRACT: Estimates of African, European, and Amerindian contributions to the gene pool of 11 predominantly African-derived South American populations were obtained using five autosomal and one Y chromosome hypervariable loci, as well as mitochondrial DNA (sequences of the first hypervariable segment of the control region, plus two restriction sites and the presence or absence of the CoII/tRNA(Lys) intergenic 9-bp deletion). The three latter characteristics are reported here for the first time for 42 individuals living in three Brazilian populations. Thirty-eight sequences were identified in these persons; 17 (45%) could be classified as being of African, 4 (11%) of Amerindian, and 2 (5%) of European origin. Evidence for asymmetrical matings in relation to sex and ethnic group was obtained for nine of the 11 populations. The most consistent finding was the introduction of European genes through males, but the results differ in the several communities, indicating the importance of local factors in such interactions. Am. J. Hum. Biol. 11:551-563, 1999. Copyright 1999 Wiley-Liss, Inc.
    American Journal of Human Biology 02/1999; 11(4):551-563. DOI:10.1002/(SICI)1520-6300(1999)11:4<551::AID-AJHB15>3.0.CO;2-Z · 1.70 Impact Factor