Genome Sequence of an Unusual Human G10P[8] Rotavirus Detected in Vietnam

Division of Virology, Kawasaki City Institute of Public Health, Oshima, Kawasaki-ku, Kawasaki-shi, Kanagawa, Japan.
Journal of Virology (Impact Factor: 4.65). 09/2012; 86(18):10236-7. DOI: 10.1128/JVI.01588-12
Source: PubMed

ABSTRACT A rare human G10P[8] rotavirus with a reassortment between bovine and human viruses was detected from a patient with acute gastroenteritis in Vietnam. Genetic analysis using complete coding sequences of all segments showed a genomic constellation of this virus of G10-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Its VP7 region was genetically related to that of a bovine rotavirus derived from Australia (strain VICG10.01), whereas all other genes were identical to those of a human rotavirus derived from Australia (strain Victoria/CK00047). These results indicate a possibility that the reassortment of the rotavirus was caused by immune escape in Australia and the rotavirus was carried to Vietnam. Additionally, this finding will help further understanding the evolution of rotaviruses circulating in Vietnam.

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