Recurrence risk of preterm birth in subsequent singleton pregnancy after preterm twin delivery

Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, the Netherlands. Electronic address: .
American journal of obstetrics and gynecology (Impact Factor: 4.7). 07/2012; 207(4):279.e1-7. DOI: 10.1016/j.ajog.2012.07.026
Source: PubMed


The purpose of this study was to investigate the recurrence risk of preterm birth (<37 weeks' gestation) in a subsequent singleton pregnancy after a previous nulliparous preterm twin delivery.
We included 1957 women who delivered a twin gestation and a subsequent singleton pregnancy from the Netherlands Perinatal Registry. We compared the outcome of subsequent singleton pregnancy of women with a history of preterm delivery to the pregnancy outcome of women with a history of term twin delivery.
Preterm birth in the twin pregnancy occurred in 1075 women (55%) vs 882 women (45%) who delivered at term. The risk of subsequent spontaneous singleton preterm birth was significantly higher after preterm twin delivery (5.2% vs 0.8%; odds ratio, 6.9; 95% confidence interval, 3.1-15.2).
Women who deliver a twin pregnancy are at greater risk for delivering prematurely in a subsequent singleton pregnancy.

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