The First Synthesis of an Epidiselenodiketopiperazine

Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States, and The Broad Institute , Infectious Disease Initiative, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
Organic Letters (Impact Factor: 6.36). 08/2012; 14(17):4534-6. DOI: 10.1021/ol3020094
Source: PubMed


Epidithiodiketopiperazines (ETPs) are natural products (e.g., gliotoxin) with varied and important biological activity, which often is attributed to the redox properties of the disulfide moiety. As such, analogs with altered redox properties and similar structural characteristics would be of value to biological investigations. The use of an ETP as the point of departure in the first synthesis of an epidiselenodiketopiperazine (ESeP) and its activity against Mycobacterium tuberculosis (MTB) is reported.

12 Reads
Show more