Article

SEN virus detection in thalassemic patients infected with hepatitis C virus.

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Blood Transfusion Organization, Hemmat highway, 146651157, Tehran, Iran.
Archives of Virology (impact factor: 2.11). 08/2012; DOI:10.1007/s00705-012-1443-3
Source: PubMed

ABSTRACT HCV infection is known to be associated with clinical complications in thalassemic patients. D and H genotypes of SEN virus (SENV) are associated with blood-product transfusion and possibly non-A-to-E hepatitis. In this study, SENV viremia and its effect on liver ALT level in thalassemic patients, thalassemic patients infected with HCV, and HCV-infected patients were examined. Semi-nested PCR was conducted for detection of genotype H and D DNA, and the level of alanine aminotransferase (ALT) was measured. There was no significant difference in the mean ALT level in the studied groups and between SENV-positive and SENV-negative individuals. The results also showed that SENV infection does not affect the ALT level in these patients.

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Keywords

alanine aminotransferase
 
ALT
 
ALT level
 
blood-product transfusion
 
clinical complications
 
D DNA
 
H genotypes
 
HCV
 
HCV infection
 
HCV-infected patients
 
liver ALT level
 
mean ALT level
 
non-A-to-E hepatitis
 
Semi-nested PCR
 
SENV
 
SENV infection
 
SENV viremia
 
SENV-negative individuals
 
studied groups
 
thalassemic patients
 

Hadi Omidi Sani