Impact of infection or vaccination on pre-existing serological memory

Oregon National Primate Research Center, Oregon Health & Sciences University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Human immunology (Impact Factor: 2.14). 08/2012; 73(11):1082-6. DOI: 10.1016/j.humimm.2012.07.328
Source: PubMed


Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1-3years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins (tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.

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