Cardiac manifestations of cutaneous disorders
ABSTRACT A number of cutaneous disorders encountered by the dermatologist have overlapping cardiac pathology. In recent years, many genetic linkages common to pathological processes in the cutaneous and cardiovascular systems have been identified. This review will describe primary cutaneous disorders with potential cardiac manifestations, including congenital syndromes, inherited cutaneous disorders associated with later cardiovascular disease, and syndromes associated with early cardiovascular pathology. The dermatologist may be the first to diagnose cutaneous findings associated with underlying cardiovascular disease; therefore, it is of prime importance for the dermatologist to be aware of these associations and to direct the appropriate workup.
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ABSTRACT: Woolly hair is an uncommon condition among non-black people, which may be an isolated finding or associated with additional clinical symptoms. When woolly hair is accompanied by palmoplantar keratoderma, it may herald a deadly cardiomyopathy, and therefore this condition should alert the physician for a heart disorder. Until recently, the underlying causes for this rare phenotype were obscure, and only three genes were associated with this condition. However, in recent years, many more genes were found to underlie this disorder, uncovering new molecular pathways. Better knowledge of the different mechanisms that control the curliness of hair may offer new treatment options for this condition, and may also make it possible to affect hair texture in general. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Journal of Medical Genetics 01/2015; 52(4). DOI:10.1136/jmedgenet-2014-102630 · 5.64 Impact Factor
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ABSTRACT: Cutaneous myxomas also called angiomyxomas are rare benign connective tissue tumours, composed of stellate cells, set in a loose mucoid stroma. These lesions have been recognized as part of Carney complex. We report a 12 year old boy affected by multiple Superficial Angiomyxomas without any other components of Carney complex. Introduction In 1988, Allen et al, proposed the disease entity 'superficial angiomyxoma which is a dermal or subcutaneous tumour composed of a mixture of small blood vessels and sparse spindle-shaped cells in a prominent myxoid stroma. Cutaneous myxomas have been well recognized in recent years, especially as part of the autosomal dominant complex of endocrine hyperactivity now known as Carney's complex. We herein report a case of Cutaneous Angiomyxomas limited to skin and subcutaneous tissue for its rarity. Case Report A 12 year old boy presented with asymptomatic multiple swellings of 15 days duration (Fig. 1a -c). The swellings appeared over both the hands and spread to forearms, forehead, chin, nose, and lower back. They were painless, non tender, non reducible, non pulsatile and soft to firm in consistency measuring about 1x1 to 2x2 cm in size. Skin over the swellings appeared normal. A differential diagnosis of Cysticercosis cellulose cutis, Cutaneous myxomas, and Lipomas was considered. Physician and Cardiologist were consulted. Routine blood, urine and stool examination was within normal limits, except raised triglycerides. Serological test for rheumatoid factor, ASLO titer was negative. ECG and ECHO were normal. Radiological examination of hands, skull and chest was normal. On USG, nodules were found in the subcutaneous plane,