Growth failure in children with cystic fibrosis

Department of Pediatrics, University of Chieti, Italy.
Journal of pediatric endocrinology & metabolism: JPEM (Impact Factor: 1). 06/2012; 25(5-6):393-405. DOI: 10.1515/jpem-2012-0012
Source: PubMed


Poor linear growth and inadequate weight gain are very common problems in cystic fibrosis (CF) children. The most important factors involved in growth failure are undernutrition or malnutrition, chronic inflammation, lung disease, and corticosteroid treatment. Nutritional support and pharmacological therapy with recombinant human growth hormone are essential for a good management of children with CF, although these children are shorter and lighter than healthy children, and despite the catch-up growth observed after diagnosis, deficit in length/height and weight continues to be seen until adulthood. Early diagnosis is essential to ensure better nutritional status and growth, potentially associated with better respiratory function and prognosis. The aims of this review are try to explain etiology and pathogenetic mechanisms of growth failure in CF children and clarify their role in the disease morbidity and in clinical outcome, especially in relation to progressive decline of pulmonary function.

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    • "One of the explanations for this is improved nutrition and improved understanding of the cellular defects in this disorder (Lyczak et al., 2002). It is believed that nutritional management, together with infectious aspects, are two fundamental parameters to be followed in this field of research (Scaparrotta et al., 2012), as besides the complex genetic background, most cases with cystic fibrosis present increased susceptibility to infections and changes in nutritional status. There is an important interaction between these two factors. "

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