Article

Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.

Research and Development of Novel Drugs Unit, Center for Applied Pharmacobiology Research-CIFA, University of Navarre, Pamplona 31080, Spain.
Molecules (impact factor: 2.39). 01/2012; 17(8):9451-61. DOI:10.3390/molecules17089451 pp.9451-61
Source: PubMed

ABSTRACT Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.

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Keywords

antileishmanial activity
 
axenic forms
 
erythrocytic forms
 
good activity
 
Leishmania infantum
 
leishmanicidal properties
 
Malaria
 
new 2-cyano-3-(4-phenylpiperazine-1-carboxamido)
 
normal monkey kidney cells
 
Plasmodium falciparum
 
tropical parasitic diseases
 
VERO cells
 
vitro antimalarial