Highly selective fluorescence turn-on sensing of gold ions by a nanoparticle generation/C-I bond cleavage sequence

Department of Chemistry, Institute of Nanosensor and Biotechnology, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701, Korea.
The Analyst (Impact Factor: 4.11). 08/2012; 137(19):4411-4. DOI: 10.1039/c2an35351b
Source: PubMed


We have developed a quickly responsive, and specific fluorescent assay for the detection of Au(III) on the basis of the formation of gold nanoparticles in the presence of HEPES, which cleave the C-I bond of I-BODIPY 1 to yield the highly fluorescent H-BODIPY 2.

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Available from: Jihye Park, Dec 08, 2014
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    • "Fluorimetry, in conjunction with suitable probes, is a preferable approach for the detection of trace levels of metal ions because this fluorescence-based method can be performed rapidly, is nondestructive , highly sensitive, and can provide real information on the localization and quantity, which is crucial to elucidate the functions of metal ions in biological systems [18] [19] [20] [21] [22]. To date, several gold ion-selective molecular probes based on various fluorophores such as rhodamine [23] [24] [25] [26] [27] [28] [29] [30], fluorescein [31] [32], BODIPY [33] [34] [35], naphthalimide [36] [37], coumarine [38] [39] [40], rhodamine- BODIPY coupling [41] [42] etc., have been reported. As a classic fluorophore, fluorescein possesses advantages such as good water solubility, visible excitation and emission, and maximum brightness at physiological pH [43]. "
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    • "mg/L gold in the surface waters of Gossan Creek, Canada. (detection limit for inductivelycoupled plasma emission spectrometry was not presented) Some published literature has reported that gold may induce damage to living organisms because it conglutinates to biomolecules (such as enzymes and DNA) (Nyarko et al., 2004; Park et al., 2012). In particular, existing toxicity data for gold (III) ion (Au 3þ ) has been presented in previous studies using fish (Buhl and Hamilton, 1991; Jones, 1939), waterfleas (Biesinger and Christensen, 1972; Li et al., 2010), amphipods (Borgmann et al., 2005), flatworms (Jones, 1940), and green algae (Stokes, 1981) (Table 1). "
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