Subclinical hypopituitarism

Endocrinology Division, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Departamento de Medicina, Universidad de Santiago de Compostela, Travesía da Choupana s/n. 15706 Santiago de Compostela, La Coruña, Spain.
Best Practice & Research: Clinical Endocrinology & Metabolism (Impact Factor: 4.6). 08/2012; 26(4):461-9. DOI: 10.1016/j.beem.2011.10.007
Source: PubMed


The presence of subclinical or minor pituitary hormone deficiencies could be recognised in clinical practice and might represent intermediate situations among normal pituitary hormone secretion and clinical hypopituitarism. However, this entity has not been correctly identified and associated clinical impairment and even more, long-term consequences regarding to morbidity and mortality, strongly related to clinical hypopituitarism, has not been correctly settled. Furthermore, best test or methods for diagnosis and the cut off to define these intermediate situates are also unknown. With this purpose, long-term controlled studies are needed to define correctly this entity, the appropriate methods for diagnosis and the potential benefits of substitutive hormone therapy in detected cases. The present review will focus on the available evidence concerning the prevalence, clinical features and diagnosis of subclinical hypopituitarism.

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    ABSTRACT: Background: The panhypopituitarism is a rare endocrine system disease; the clinical presentation of a panhypopituitarism patient can vary from asymptomatic or subclinical cases to life-threatening myxedema coma. Case report: Our patient is a 55 years old woman who was presented to emergency department with chief complains of weakness. After necessary workup, panhypopituitarism was diagnosed. Discussion: There are different diagnoses for weakness. In patients with vague complaints such as weakness, we should take their history carefully and perform clinical examinations to reach a definitive diagnosis.
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