Photodynamic activity of viral nanoparticles conjugated with C60.

Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Chemical Communications (Impact Factor: 6.38). 08/2012; 48(72):9044-6. DOI: 10.1039/c2cc34695h
Source: PubMed

ABSTRACT The development of viral nanoparticles (VNP) displaying multiple copies of the buckyball (C(60)) and their photodynamic activity is described. VNP-C(60) conjugates were assembled using click chemistry. Cell uptake and cell killing using white light therapy and a prostate cancer cell line is demonstrated.

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