Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model
Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus, . Annals of Biomedical Engineering
(Impact Factor: 3.23).
08/2012; 41(1). DOI: 10.1007/s10439-012-0630-4
Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To overcome this outstanding problem, a better understanding of how the physical properties (i.e., size, surface chemistry, and shape) of nanoparticles affect their transvascular transport in tumors is required. In this study, we developed a mathematical model for nanoparticle delivery to solid tumors taking into account electrostatic interactions between the particles and the negatively-charged pores of the vessel wall. The model predictions suggest that electrostatic repulsion has a minor effect on the transvascular transport of nanoparticles. On the contrary, electrostatic attraction, caused even by small cationic charges (surface charge density less than 3 × 10(-3) C/m(2)) can lead to a twofold or more increase in the transvascular flux of nanoparticles into the tumor interstitial space. Importantly, for every nanoparticle size, there is a value of charge density above which a steep increase in transvascular transport is predicted. Our model provides important guidelines for the optimal design of nanoparticle formulation for delivery to solid tumors.
Available from: Katarzyna A Rejniak
- "Examples of typical outcomes from various mathematical models of drug penetration through the tumor tissue. (A) A hybrid model of tumor mass and discrete vasculature (left, red-tumor tissue, brown-vasculature) was used to investigate fluid and drug extravasation from the vasculature (right, color corresponds to drug concentration) [from Wu et al. (37), Figure 18]; (B) Patterns of diffusion-(top) and advection-(bottom) dominated transport of drug molecules (red dots) through the interstitial space between the cells (white circles) [from Rejniak et al. (58), Figure 6]; (C) A gradient of the interstitial fluid pressure (top) and transvascular pressure differences (bottom) in the growing tumor mass [from Stylianopoulos et al. (30), Figure 2]; (D) A drug concentration gradient from the vessel (white) outward with colors representing high (yellow) and low (brown) levels of diffusive drug [from Thurber et al. (17), Figure 8]; (E) Spatial distributions of hypoxic (yellow), necrotic (black), and apoptotic (green) tumor cells within the tumor mass treated with angiogenesis inhibitors for 37 weeks; the treatment is supplied from vasculature (red) [from Gevertz (34), Fig.3]; (F) Structural adaptation of vessel diameters (colors represent the volume of blood flow) inside the tumors [from Pries et al. (31), Figure 6]. All figures reprinted with permissions. "
[Show abstract] [Hide abstract]
ABSTRACT: Delivery of anti-cancer drugs to tumor tissues, including their interstitial transport and cellular uptake, is a complex process involving various biochemical, mechanical, and biophysical factors. Mathematical modeling provides a means through which to understand this complexity better, as well as to examine interactions between contributing components in a systematic way via computational simulations and quantitative analyses. In this review, we present the current state of mathematical modeling approaches that address phenomena related to drug delivery. We describe how various types of models were used to predict spatio-temporal distributions of drugs within the tumor tissue, to simulate different ways to overcome barriers to drug transport, or to optimize treatment schedules. Finally, we discuss how integration of mathematical modeling with experimental or clinical data can provide better tools to understand the drug delivery process, in particular to examine the specific tissue- or compound-related factors that limit drug penetration through tumors. Such tools will be important in designing new chemotherapy targets and optimal treatment strategies, as well as in developing non-invasive diagnosis to monitor treatment response and detect tumor recurrence.
Frontiers in Oncology 11/2013; 3:278. DOI:10.3389/fonc.2013.00278
[Show abstract] [Hide abstract]
ABSTRACT: Detailed arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.
Angewandte Chemie International Edition 01/2013; 125(5). DOI:10.1002/anie.201208331 · 11.26 Impact Factor
Available from: Triantafyllos Stylianopoulos
Therapeutic delivery 04/2013; 4(4):421-3. DOI:10.4155/tde.13.8
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.