Article

Hepatitis C virus quantification in serum and saliva of HCV-infected patients.

Laboratório de Patologia e Biologia Molecular-Fiocruz, Rua Waldemar Falcão 121, 40296-710 Salvador, BA, Brasil.
Memórias do Instituto Oswaldo Cruz (impact factor: 2.15). 08/2012; 107(5):680-3. pp.680-3
Source: PubMed

ABSTRACT The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients. Twenty-nine patients with detectable HCV RNA in their serum and saliva were included in this study. The HCV viral loads were determined through quantitative real-time polymerase chain reactions. The median viral RNA levels were 5.78 log10 copies in the serum and 3.32 log10 copies in the saliva. We observed that the salivary HCV viral load was significantly lower than the viral load in the serum. Further studies are required to understand the role of saliva in the diagnosis, management and potential transmission of HCV.

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Keywords

bodily fluids
 
detectable HCV RNA
 
HCV
 
HCV viral loads
 
median viral RNA levels
 
patients
 
potential transmission
 
quantitative real-time polymerase chain reactions
 
salivary HCV viral load
 
semen
 
viral load