Case Scenario: Perioperative Administration of Tocotrienols and Green Tea Extract in a Child with Familial Dysautonomia
Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4399, USA.Anesthesiology (Impact Factor: 5.88). 07/2012; 117(3):639-45. DOI: 10.1097/ALN.0b013e318267084d
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ABSTRACT: The incidence of childhood neurodevelopmental disorders, which include autism, attention deficit hyperactivity disorders, and apraxia, are increasing worldwide and have a profound impact on these individuals’ behaviors, cognitive skills, mood and self-esteem. While the etiology of these disorders are unclear, they often accompany genetic and biochemical abnormalities resulting in cognitive and communication difficulties. Because cognitive and neural development require essential fatty acids (particularly long chain ω-3 fatty acids often lacking in mother’s and children’s diets) during critical growth periods, the potential behavior-modifying effects of these fatty acids as “brain nutrients” has attracted considerable attention. Additionally, there is compelling evidence for increased oxidative stress, altered antioxidant defenses, and neuroinflammation in these children. The purpose of this commentary is to provide a scientific rationale based upon cellular, experimental animal model, observational and clinical intervention studies for incorporating the combination of ω-3 fatty acids and tocotrienol-rich vitamin E as complementary nutritional therapies in children with neurodevelopmental disorders. Should this nutritional combination correct key clinical or biochemical outcomes and/or improve behavioral patterns, it would provide a safe, complementary option for these children.Nutrition 01/2013; 30(7-8). DOI:10.1016/j.nut.2013.11.001 · 2.93 Impact Factor
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