[Show abstract][Hide abstract] ABSTRACT: Reconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of infection is often associated with an unfavourable ratio of dosage efficiency and toxic effect. Thus, the present study aims to find a new factor which may improve antibacterial activity while also presenting low toxicity to the human cells. Such factors are usually implemented along with the implant itself and may be an integral part of it. Many recent studies have focused on inorganic factors, such as metal nanoparticles, salts, and metal oxides. The advantages of inorganic factors include the ease with which they can be combined with ceramic and polymeric biomaterials. The following review focuses on hydroxyapatites substituted with ions with antibacterial properties. It considers materials that have already been applied in regenerative medicine (e.g., hydroxyapatites with silver ions) and those that are only at the preliminary stage of research and which could potentially be used in implantology or dentistry. We present methods for the synthesis of modified apatites and the antibacterial mechanisms of various ions as well as their antibacterial efficiency.
BioMed Research International 05/2014; 2014(2):178123. DOI:10.1155/2014/178123 · 3.17 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Characterization, antibacterial and in vitro compatibility of zinc-silver doped hydroxyapatite nanoparticles prepared through microwave synthesis, Ceramics Interna-tional, http://dx.doi.org/10.1016/j.ceramint.2013.08.125 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
[Show abstract][Hide abstract] ABSTRACT: To improve the osteogenic and anti-bacterial activity for the hydroxyapatite coated titanium substrate Zn containing HA biological coating was prepared on commercially pure Ti via the sol-gel method after treatment by oxidation which produced a porous titania coating on the titanium. The phase structures of the coatings were characterized by X-ray diffraction. The release concentration of zinc was measured by an inductively coupled plasma spectrometer. In vitro co-culture assays were performed to evaluate the cell morphology and attachment of MG-63 cells to the coated titanium. The anti-bacterial effect of the ZnHA/TiO2 coating was evaluated on Porphyromonas gingivalis w83. The cell micro morphology on the ZnHA/TiO2 coatings was more polygonal than that of HA/TiO2 coatings when viewed by SEM. It was confirmed by fluorescence microscopy observations that the MG-63 cells on the hybrid coating layer were favorably adhered. Compared with the HA/TiO2 coating, the ZnHA/TiO2 coating significantly inhibited the growth of Porphyromonas gingivalis. The results suggest that the ZnHA/TiO2 hybrid coatings on titanium implants should possess better mechanical binding properties and biocompatibility.
Journal of Hard Tissue Biology 01/2013; 22(3):311-318. DOI:10.2485/jhtb.22.311 · 0.32 Impact Factor
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