Imaging markers of incipient dementia The white matter matters
Correspondence & reprint requests to Dr. Carmichael: . Neurology
(Impact Factor: 8.29).
07/2012; 79(8):726-7. DOI: 10.1212/WNL.0b013e3182662020
Dementia researchers are struggling to clarify the clinical relevance of a brain imaging finding that is common among cognitively healthy elderly individuals.(1) It is associated with increased risk of clinical dementia,(2) but the time course of this progression is not fully understood. It may begin to occur as early as the fifth or sixth decade of life(3) and may persist for many years before clinical symptoms become apparent. There are good reasons to believe that the neurobiological events giving rise to this imaging finding are deleterious. However, it is currently not known whether prevention or reversal of these events is sufficient to prevent a cascade of brain injury processes that eventually culminates in clinical dementia.
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