Sleep-disordered breathing symptoms among African-Americans in the Jackson Heart Study

School of Medicine, University of Mississippi Medical Center, Jackson, MS 39216-4505, United States.
Sleep Medicine (Impact Factor: 3.1). 07/2012; 13(8):1039-49. DOI: 10.1016/j.sleep.2012.06.005
Source: PubMed

ABSTRACT Sleep-disordered breathing (SDB) is an increasingly recognized risk factor for cardiovascular disease (CVD). Limited data are available from large African American cohorts.
We examined the prevalence, burden, and correlates of sleep symptoms suggestive of SDB and risk for obstructive sleep apnea (OSA) in the Jackson Heart Study (JHS), an all-African-American cohort of 5301 adults. Data on selected daytime and nighttime sleep symptoms were collected using a modified Berlin questionnaire during the baseline examination. Risk of OSA was calculated according to published prediction model. Age and multivariable-adjusted logistic regression models were used to examine the associations between potential risk factors and measures of sleep.
Sleep symptoms, burden, and risk of OSA were high among men and women in the JHS and increased with age and obesity. Being married was positively associated with sleep symptoms among women. In men, poor to fair perceived health and increased levels of stress were associated with higher odds of sleep burden, whereas prevalent hypertension and CVD were associated with higher odds of OSA risk. Similar associations were observed among women with slight variations. Sleep duration <7h was associated with increased odds of sleep symptoms among women and increased sleep burden among men. Moderate to severe restless sleep was consistently and positively associated with odds of adverse sleep symptoms, sleep burden, and high risk OSA.
Sleep symptoms in JHS had a strong positive association with features of visceral obesity, stress, and poor perceived health. With increasing obesity among younger African Americans, these findings are likely to have broad public health implications.

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    • "[9]; therefore, ethnic differences may diminish with extreme age. Another study from a large singlesite cohort of black adults found that the risk of obstructive sleep apnea, one of the most common sleep-related breathing disorders, was 3.5% among men and 16.8% among women [10]. This prevalence among black men was comparable to the prevalence rates among white men (4%), whereas the prevalence among black women is substantially larger than that among white women (2%) [11]. "
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    • "In vivo evidence has shown that hypoxia induces angiogenesis by upregulating connective tissue growth factor in human breast cancer cells [21]. Second, obesity is a risk factor for breast cancer [22], and is highly prevalent in SA patients [23] [24]. An animal study found that both obesity and intermittent hypoxia are associated with increased tumor growth, but no synergistic effect was observed [25]. "
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