Article

Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections.

Core Trainee 2 Doctor, Department of Respiratory Medicine, West Middlesex University Hospital, London, UK.
Primary care respiratory journal: journal of the General Practice Airways Group 07/2012; 21(3):337-41. DOI:10.4104/pcrj.2012.00059 pp.337-41
Source: PubMed

ABSTRACT Nitrofurantoin is commonly used for the treatment and prophylaxis of recurrent urinary tract infections (UTIs). Although relatively rare, nitrofurantoin is one of the commonest causes of drug-induced pulmonary disease, which can be potentially serious and even fatal. Knowledge of such potential adverse effects is essential to enable early recognition and withdrawal of the drug. Patients on long-term nitrofurantoin should be reviewed and monitored regularly. Management involves early consideration of the condition, and prompt withdrawal of the drug. We report three cases of nitrofurantoin-induced lung disease in patients who were on long-term nitrofurantoin for UTI prophylaxis and present a brief review of the literature on this subject.

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Keywords

commonest causes
 
drug-induced pulmonary disease
 
fatal
 
long-term nitrofurantoin
 
Nitrofurantoin
 
nitrofurantoin-induced lung disease
 
patients
 
potential adverse effects
 
recurrent urinary tract infections