TH17, TH22 and TReg cells are enriched in the healthy human cecum

Trinity College Dublin, Ireland
PLoS ONE (Impact Factor: 3.23). 07/2012; 7(7):e41373. DOI: 10.1371/journal.pone.0041373
Source: PubMed


There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in the healthy human cecum compared to the terminal ileum and sigmoid colon, whereas T(H)1 and T(H)2 cells do not significantly vary by location. Transcriptional profiling analysis of paired pinch biopsies from different regions of the intestine identified significant differences in the metabolic state of the terminal ileum, cecum, and sigmoid colon. An increased proportion of T(H)17 cells was positively associated with expression of resistin (RETN) and negatively associated with expression of trefoil factor 1 (TFF1). These results suggest that CD4(+) T helper cells that are important in maintaining mucosal barrier function may be enriched in the cecum as a result of metabolic differences of the surrounding microenvironment.

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Available from: Png Loke, Apr 21, 2014
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    • "Whether WAT directly plays or not a major role in regulatory T cell response is yet far to be elucidated [33]. The presence of ectopic fat and adipocytes in many organs aside WAT depots should be read at the light of the complex dynamics linking WAT inflammation and the immune intestinal barrier, notoriously enriched of Treg cells [99]. Recent reports have outlined the important role of inflammation in WAT, as proinflammatory mechanisms in adipose tissue promote tissue remodelling and expansion [100]. "
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    • "Regarding Treg counts in the colonic mucosa of the control group [24] or “healthy” subjects [25] in other studies, lower frequencies were found in the sigmoid compared with the ascending colon. Within the large intestine, our observations are in good agreement with those of Wolff et al. [25], confirming that T cell frequencies observed in the relatively easily accessible sigmoid colon do not represent T cell frequencies of other regions of the gut. "
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