Article

IN VITRO EVALUATION OF ANTIMICROBIAL PROPERTIES OF Carica papaya

IJBPAS 08/2012; 7(1):933-945.

ABSTRACT In the present study Cold aqueous, hot aqueous, 70 % Ethanol, 80 % Methanol and Acetone
extracts of Carica papaya (dry leaf, green leaf, root, stem, ripe pulp, unripe pulp, ripe peel,
unripe peel and seed) in different concentrations were evaluated for their antimicrobial properties
against pathogenic microorganism such as Pseudomonas aeruginosa, Staphylococcus aureus and
Escherchia coli and fungal pathogenic microorganism Candida albicans, Aspergillus niger and
Trichophytom rubrum using agar well diffusion method. All the extracts were effective against
used pathogens but hot aqueous extract of ripe peel showed best antibacterial activity forming a
zone of inhibition of 13 mm against the Escherchia coli, which was equal to the zone of
inhibition formed by the standard antibiotic Tetracycline (500 μg/ml). 80 % methanol extract of
unripe pulp shows an average zone of inhibition of 18 mm against the Candida albicans, which
was nearly equal to the zone of inhibition of Fluconazole.

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    ABSTRACT: Carica papaya has been used in the Ethiopian traditional medicine to relieve stress and other disease conditions. The present study was undertaken to evaluate the anxiolytic and sedative effects of 80% ethanolic Carica papaya (Caricaceae) pulp extract in mice. C.papaya pulp extract was screened for anxiolytic effect by using elevated plus maze, staircase and open field tests, and ketamine-induced sleeping time test for sedation at doses of 50, 100,200, 400mg/kg. Distilled water and Diazepam were employed as negative and positive control groups, respectively. C. papaya pulp extract 100mg/kg significantly increased the percentage of open arm time and entry, and reduced the percentage of entry and time spent in closed arm in elevated plus maze test; reduced the number of rearing in the staircase test; and increased the time spent and entries in the central squares while the total number of entries into the open field were not significantly affected, suggesting anxiolytic activity without altering locomotor and sedative effects. A synergistic reduction in the number of rearing and an inverted U-shaped dose response curves were obtained with important parameters of anxiety CONCLUSIONS: The results of this study established a support for the traditional usage of C. papaya as anxiolytic medicinal plant.
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    ABSTRACT: Objective: To evaluate the antinociceptive (analgesic activity) and anti-inflammatory effect of Carica Papaya (cp) linn (Aqueous seed extract) in albino rats. Material and Methods: To evaluate antinociceptive effect of Carica Papaya Aqueous seed extract (3 doses of 5mg/kg, 10mg/kg, 20mg/kg) in albino rats by Comparing their effect with pethidine by using Radiant heat method & Contact heat method. Anti-inflammatory effect of Carica Papaya Aqueous seed extract (3 doses of 5mg/kg, 10mg/kg, 20mg/kg) was assessed comparing their effect with Aspirin in albino rats by inducing acute Inflammation – by Carrageenan-induced rat paw edema method. Results: Analgesic models: Carica Papaya Aqueous seed extract treated groups with 20mg/kg has showed significant increase in reaction time at 90 minutes when compared to control group in all the two analgesic models of experiments. These findings indicate that Carica Papaya Aqueous seed extract has a promising analgesic activity in comparison with pethidine (standard). Anti-inflammatory model : Carica Papaya Aqueous seed extract treated groups with 10mg/kg and 20mg/kg has showed significant reduction in paw edema volume at 5 hours when compared to control group in acute inflammation method. These findings indicate that Carica Papaya Aqueous seed extract was exhibiting more anti-inflammatory effect in comparison with aspirin (standard). Conclusion: Carica Papya seed extract had shown significant analgesic effect with high dose and significant anti-inflammatory effect with low dose (combination with Aspirin) , moderate dose and high dose.

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