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Spontaneous pneumothorax as a result of intensive cytotoxic chemotherapy.

Chest (Impact Factor: 7.13). 03/1979; 75(2):194-6.
Source: PubMed

ABSTRACT Spontaneous pneumothorax occurring as a complication of the antitumor effect of cytotoxic chemotherapy has been reported in occasional cases of osteogenic sarcoma. Its occurrence in other tumors has not been described. This report describes two cases of this complication in patients with germinal tumors and discusses possible pathophysiologic mechanisms.

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    ABSTRACT: Background. Spontaneous pneumothorax complicating chemotherapy has been reported mainly in metastatic sarcoma, particularly of the osteogenic type. The main factor in the etiology of spontaneous pneumothorax could be related to tumor lysis and/or rapid rupture of chemosensitive peripheral or subpleural metastasis into the pleural cavity, thus leading to a bronchopleural fistula.Methods and Results. A 49-year-old patient in whom spontaneous pneumothorax developed after successful chemotherapy for metastatic seminoma is described. On chest tube drainage, the lung reexpanded rapidly and the patient became clinically and radiographically symptom free.Conclusion. To the authors' knowledge, this is only the second case of spontaneous pneumothorax complicating chemotherapy-induced rapid regression of lung and mediastinal metastases in patients with seminoma. Spontaneous pneumothorax should be included in the spectrum of chemotherapy-related side effects in chemosensitive solid tumors with lung metastases Cancer 1995;75:2710–3.
    Cancer 06/2006; 75(11):2710 - 2713. · 5.20 Impact Factor
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    ABSTRACT: Spontaneous pneumothorax (SP) associated with malignant disease is well known but rare. Diagnosing its etiology is important for therapy. We describe SP that recurred after chemotherapy in a patient with granulosa cell tumor. An SP supposedly developed secondary to regres-sion of pulmonary metastasis and resulted in a broncho-pleural fistula. The patient recovered after draining with a chest tube and pleurodesis. Chemotherapy was continued without further complications. We discuss several mechanisms for, and the clinical association of, the SP with metastasis in a granulosa cell tumor of the ovary.
    International Cancer Conference Journal. 06/2014;
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    ABSTRACT: Objective Endometrial cancer with hematogenous metastases can be treated with chemotherapy. We present a case of spontaneous pneumothorax that occurred when a solitary pulmonary endometrial metastatic lesion was treated with paclitaxel plus carboplatin. Case report A 38-year-old female had stage II endometrial endometrioid adenocarcinoma. Solitary bilateral pulmonary metastases developed after primary treatment. Complete remission accompanied by a right spontaneous pneumothorax occurred during chemotherapy with paclitaxel plus carboplatin. Conclusion Rapid shrinkage of a pulmonary space-occupying tumor sometimes causes rare but life-threatening spontaneous pneumothoraces. We report the first case of a spontaneous pneumothorax after using paclitaxel plus carboplatin in the treatment of endometrial cancer.
    Taiwanese Journal of Obstetrics and Gynecology 06/2014; 53(2):245–247. · 1.26 Impact Factor

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