Spontaneous pneumothorax as a result of intensive cytotoxic chemotherapy

Chest (Impact Factor: 7.48). 03/1979; 75(2):194-6.
Source: PubMed


Spontaneous pneumothorax occurring as a complication of the antitumor effect of cytotoxic chemotherapy has been reported in occasional cases of osteogenic sarcoma. Its occurrence in other tumors has not been described. This report describes two cases of this complication in patients with germinal tumors and discusses possible pathophysiologic mechanisms.

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    • "It is estimated that less than 1% of all SP are tumor-associated [1] [10]. Metastatic osteogenic or soft tissue sarcoma are most commonly associated with pneumothorax, particularly in the setting of administration of cytotoxic chemotherapy [4] [5] or radiation [8]. In the majority of these previously reported cases, the patients either had known metastatic pulmonary disease or the diagnosis was rapidly suggested by nodules detected by imaging modalities. "
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    ABSTRACT: We present two cases of spontaneous pneumothorax secondary to metastatic synovial cell sarcoma. Radiographic techniques initially did not suggest lung nodules in either patients; thoracoscopy allowed sequential bilateral detection of small pulmonary metastases in one case and confirmed the diagnosis during treatment of recurrent pneumothorax in the second case. This report underlines that pneumothorax may be the first clinical manifestation of metastatic sarcoma and can occur even if current imaging techniques are not indicative of metastatic disease. In the latter instance, thoracoscopic exploration has to be envisaged in order to rule out the possibility of metastatic lung involvement.
    European Journal of Cardio-Thoracic Surgery 07/1997; 11(6):1171-3. DOI:10.1016/S1010-7940(97)01164-0 · 3.30 Impact Factor
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    ABSTRACT: Two patients with pulmonary metastases from synovial sarcoma and germ-cell tumor developed first bilateral, then repeated unilateral pneumothoraces during combination chemotherapy. It is suggested that chemotherapy may occasionally cause pneumothorax.
    Cancer 05/1981; 47(7):1743-5. DOI:10.1002/1097-0142(19810401)47:73.0.CO;2-G · 4.89 Impact Factor
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