Article

Synthesis and Anti‐inflammatory Activity of Some 1‐Methyl‐5‐(4‐substituted benzoyl)imidazole‐2‐acetates

Pharmacy and Pharmacology Communications 02/2010; 5(4):273 - 275. DOI: 10.1211/146080899128734839

ABSTRACT 1-Methyl-5-(4-X-benzoyl)imidazole-2-acetates were synthesized and tested for anti-inflammatory activity. Tolmetin and aspirin were used as reference drugs.The most active compound against carrageenan-induced oedema in rat hindpaw was a 4-chlorobenzoyl derivative, which was almost 1–5-times more active than the reference drug aspirin. In addition, it had half the activity of tolmetin.

0 Bookmarks
 · 
71 Views

Full-text

View
11 Downloads
Available from
Jun 2, 2014