Production of 13N‐labelled molecular nitrogen for pulmonary function studies

Department of Nuclear Medicine and Lung Function Laboratory, University of Groningen, The Netherlands
Journal of Labelled Compounds 07/2006; 18(3):303 - 308. DOI: 10.1002/jlcr.2580180304

ABSTRACT A method for the production of 13NN either as a gas or as an injectable solution is described. The method is based on the 16O(p,α)13N reaction and water as target material. Following irradiation, the 13NO and 13NO are reduced to 13NH3, followed by NaOBr oxidation to 13NN. With a beam current of 1 μA and 20 min irradiation time the injectable solution contained 148 MBq (4 mCi) per ml.