The aim of the present study was to examine the efficacy of various seed extracts of Terminalia chebula as an antifungal potential against certain important plant pathogenic fungi. The organic extracts of methanol, ethyl acetate and chloroform at the used concentration of 1500 ppm/disc revealed remarkable antifungal effect as a fungal mycelial growth inhibitor against Fusarium oxysporum, Fusarium solani, Phytophthora capsici and Botrytis cinerea, in the range of 41.6–61.3%, along with MIC values ranging from 62.5 to 500 μg/ml. Also, the extracts had a strong detrimental effect on spore germination of all the tested plant pathogens along with concentration as well as time-dependent kinetic inhibition of B. cinerea. The results obtained from this study suggest that the natural products derived from Terminalia chebula could become an alternative to synthetic fungicides for controlling such important plant pathogenic fungi.
"The fruits have different names in different parts of the world; Haritaki, Harad, Hirada (subcontinent), Aralu (Sri Lanka), Zhang-Qin-Ge, Hezi (China), Harra Harro (Tibet), Myrobalane (Germany) and Myrobalan in dien (France) (SuryaPrakash et al., 2012). Ayurvedic and homeo-medicines have been using this fruit to treat various diseases due to its broad spectrum antibacterial (Malekzadeh et al., 2001), antifungal and anti-stress properties (Bajpai et al., 2010; Singh and Kumar, 2013). There are reports that compounds present in this fruit can be used to cure cancer (Saleem et al., 2002). "
[Show abstract][Hide abstract] ABSTRACT: Over the centuries plants have ben efectively used as a potent source of traditonal medicine. Present experiment was
aimed to evaluate the hypocholesterolemic and anti-atherogenic efect of feding Terminalia chebula powder (TCP) in
rabits. A total of (n=20) rabits were asigned to four treatment groups with n=5 animals in each group. Experimental
treatments received Normal Saline (NS); T. chebula powder (TCP), high fat diet (HFD) and high fat diet plus T. chebula
powder (HFDTCP). Blod samples were taken on a wekly basis to diagnose the efects of test drug on serum Total
Cholesterol (TC), LDL, HDL, Triglycerides (TG) and Atherogenic Index. Al the parameters were measured in mg/dl
except the atherogenic index measured in units. In HFD rabits TC (362.59±6.0), LDL (262.59±6.12) triglycerides
(258.7±2.90) and atherogenic index (13.50±1.20) was higher (p <0.05), while HDL (25.73±1.09) was significantly
reduced to an alarming level at the end of eight weks. When HFD rabits were treated with TCP for eight weks, TC
(132.60±4.93), LDL (89.13±2.75), Triglycerides (125.86±9.06) and atherogenic index (1.54±0.03) reduced significantly
and increased (p <0.05) the HDL (52.10±1.50). It was therefore concluded thathat T. chebula powder can safely be used
to reduce bad cholesterol (LDL) and to enhance god cholesterol (HDL).
Key words: Medicinal plants, Terminalia chebula, HDL, LDL, Hypercholesteremia, Atherogenic Index
Journal of Animal and Plant Sciences 12/2014; 24(6):1618-1622. · 0.45 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The role of plant extracts and Ayurvedic polyherbal preparations in treating various ailments has been acknowledged since time immemorial. Studies based on the effect of these extracts in treatment of different diseases have also been well documented. Indian medicinal literature also emphasizes the synergistic effect of polyherbal drugs in restoring and rejuvenating immune system. This review focuses on the immunomodulatory potential of the polyherbal preparation, Triphala and its three constituents, Terminalia bellerica, Terminalia chebula and Emblica officinalis. The role of Triphala and its extract has been emphasized in stimulating neutrophil function. Under stress condition such as noise, Triphala significantly prevents elevation of IL-4 levels as well as corrects decreased IL-2 and IFN-γ levels. Under the condition of inflammatory stress its immunosuppressive activity is attributed to its inhibitory action on complement system, humoral immunity, cell mediated immunity and mitogen-induced T-lymphocyte proliferation. The aqueous and alcoholic extracts of the individual constituents reportedly enhance especially the macrophage activation due to their free radical scavenging activity and the ability to neutralize reactive oxygen species. This study thus concludes the use of Triphala and its three individual constituents as potential immunostimulants and/or immunosuppressants further suggests them to be a better alternative for allopathic immunomodulators.
Indian Journal of Pharmaceutical Sciences 11/2014; 76(6):467-75. · 0.48 Impact Factor
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