Synthesis and characterization of functionalized water soluble cationic poly(ester amide)s
Journal of Polymer Science Part A Polymer Chemistry (Impact Factor: 3.54). 07/2010; 48(17):3758 - 3766. DOI:10.1002/pola.24160
- Journal of Polymer Science Part A Polymer Chemistry 08/2008; 46(19):6376 - 6392. · 3.54 Impact Factor
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ABSTRACT: In this paper, a new kind of aliphatic biodegradable polyesteramide copolymers P(CL/AU)x/y based on ε-caprolactone and 11-aminoundecanoic acid were synthesized by the melt polycondensation method. Hydrolytic degradation behavior of P(CL/AU) copolymers were studied by using FTIR, 1H-NMR and DSC. Chemical compositions, macromolecular weight, thickness of the test sample, and pH of the degradation medium have great effect on degradation rate. The degradation rate decreased with increase in aminoundecanoic acid content, macromolecular weight, and thickness of the test samples, but increased with incubation temperature and pH of the degradation medium. The degradation mechanism was studied according to the mathematical model developed by professor Göpferich.Biomaterials 01/2004; 25(11):1975-1981. · 7.60 Impact Factor
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ABSTRACT: Nowadays the open and the patent literatures propose a large number of polymers whose main chains can be degraded usefully. Among these degradable polymers, aliphatic polyester-based polymeric structures are receiving special attention because they are all more or less sensitive to hydrolytic degradation, a feature of interest when compared with the fact that living systems function in aqueous media. Only some of these aliphatic polyesters are enzymatically degradable. A smaller number is biodegradable, and an even more limited number is biorecyclable. To be of practical interest, a degradable polymer must fulfill many requirements that depend very much on the targeted application, on the considered living system, and on living conditions. It is shown that aliphatic polyester structures made of repeating units that can generate metabolites upon degradation or biodegradation like poly(beta-hydroxy alkanoate)s and poly(alpha-hydroxy alkanoate)s are of special interest. Their main characteristics are confronted to the specifications required by various potential sectors of applications, namely, surgery, pharmacology, and the environment. It is shown that degradation, bioresorption, and biorecycling that are targets when one wants to respect living systems are also drastic limiting factors when one wants to achieve a device of practical interest. Finding a universal polymer that would be the source of all the polymeric biomaterials needed to work in contact with living organisms of the various life kingdoms and respect them remains a dream. On the other hand, finding one polymeric structure than can fulfill the requirements of one niche application remains a big issue.Biomacromolecules 01/2005; 6(2):538-46. · 5.37 Impact Factor
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