AFM Snapshots of Synthetic Multifunctional Pores with Polyacetylene Blockers: Pseudorotaxanes and Template Effects

Angewandte Chemie International Edition (Impact Factor: 11.34). 08/2005; 44(38):6154 - 6157. DOI: 10.1002/anie.200501886
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    ABSTRACT: In this report, we describe design, synthesis, evaluation and molecular dynamics simulations of synthetic multifunctional pores with pi-acidic naphthalenediimide clamps. Experimental evidence is provided for the formation of unstable but inert, heterogeneous and acid-insensitive dynamic tetrameric pores that are sensitive to base and ionic strength. Blockage experiments reveal that the introduction of aromatic electron donor-acceptor interactions provides access to the selective recognition of pi-basic intercalators within the pore. This breakthrough is important for the application of synthetic pores as multianalyte sensors.
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