A study of certain analgetic‐antipyretic compounds
ABSTRACT Two new compounds, α-phenyl-α-(2-piperidino-ethyl)-β-ethyl-butyric acid nitrile and 1 – phenyl −2,3 – dimethyl −4 – (phenylmethyl – morpholino) – methyl – pyrazolone-(5), have been studied by various procedures. These compounds showed no analgetic activity by a thermal method in mice, weak analgetic activity as indicated by blockade of irritant-induced writhing in mice, good antipyretic activity in rats, and no antigranulomatous activity in rats.
- Science 07/1951; 113(2944):631. · 31.03 Impact Factor