Central nervous system (CNS) depressant and Analgesic activity of methanolic extracts ofNardostachys jatamansi DC. and Coscinium fenestratum Colebr. in experimental animal model
ABSTRACT The present study was conducted to investigate the analgesic and CNS depressant property of methanol extracts of Nardostachys jatamansi DC and Coscinium fenestratum Colebr in animal model. The analgesic activity of methanol extracts was evaluated by Tail flick method. CNS depressant activity was determined using digital Actophotometer. Phytoconstituents namely phenols, alkaloids, steroids, flavonoids and glycosides were present in both the extracts. In analgesic activity, the reaction time increased significantly for the extract and standard groups when compared to the predrug treatment. The locomotor activity count in the extract and standard drug treated group was significantly reduced when compared to control group. The analgesic and CNS depressant activity of extracts was found to be more than that of the standard drug. Further studies are needed to isolate the active constituents responsible for the observed effect and to reveal the possible mechanisms of action responsible for the analgesic and CNS activity.
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ABSTRACT: A tri-substituted benzoflavone moiety (BZF) recently isolated from the methanol extract of aerial parts of the plant Passiflora incarnata Linneaus had exhibited encouraging results in countering the dependence produced by addiction-prone substances like morphine, nicotine, cannabinoids and ethyl alcohol, during the studies performed by the authors. Since the BZF moiety had exhibited significant anxiolytic properties at 10 mg/kg p.o. dose in mice, therefore, it was desirable to evaluate this potential phyto-moiety (BZF) for its own dependence-liabilities It was also deemed viable to evaluate BZF moiety for its possible usefulness in countering the dependence-liabilities associated with the chronic use of benzodiazepines keeping in light their tremendous clinical use in the management of anxiety and insomnia. Different groups of mice were administered BZF alone (10, 50 or 100 mg/kg, p.o.), and concomitantly with diazepam (20 mg/kg, p.o.) in a 21-days treatment regimen, followed by no treatments for the next 72-hours. The withdrawal effects in the form of ambulatory behavior of the treated animals were recorded on the 25th day using an Actophotometer. The BZF-alone (three doses) treated mice exhibited a normal ambulatory behavior on 25th day. Mice groups receiving co-treatments, i.e., BZF-diazepam concomitantly, also exhibited a normal ambulatory behavior in a dose-dependent manner, i.e., the higher dose of BZF (100 mg/kg) being more effective in countering the withdrawal effects of chronically administered diazepam than the lower doses (10 or 50 mg/kg). The studies revealed that the chronic administration of the BZF moiety (three doses), did not exhibit any dependence-liability of its own, even upon an abrupt cessation. Additionally, the BZF co-treatments with diazepam also prevented the incurrence of diazepam-dependence, which might be because of the aromatase enzyme inhibiting properties associated with the BZF moiety.Journal of Pharmacy and Pharmaceutical Sciences 6(2):215-22. · 2.20 Impact Factor
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ABSTRACT: A search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has progressed significantly in the past decade. This is reflected in the large number of herbal preparations for which psychotherapeutic potential has been evaluated in a variety of animal models. The objective of this review is to provide an overview of herbal extracts and constituents that have significant therapeutic effects in animal models of psychiatric illnesses. Eighty five individual herbs reviewed were classified as anxiolytic, antidepressant, neuroleptic, antidementia, or anti-substance abuse herbs. The full scientific name of each herb, herbal part used, active constituent, extract, dose range and route, animal model, possible mechanisms of action, and pertinent references are presented via synoptic tables. The herbal mixtures were also mentioned. A considerable number of herbal constituents whose behavioral effects and pharmacological actions have been well characterized may be good candidates for further investigations that may ultimately result in clinical use. The investigation of a large portion of the herbal extracts and herbal mixtures is in its infancy. Herbal remedies that have demonstrable psychotherapeutic activities have provided a potential to psychiatric pharmaceuticals and deserve increased attention in future studies.Life Sciences 09/2004; 75(14):1659-99. · 2.56 Impact Factor
- Indian Drugs 01/2006; 43:150-152.