Efficacy of 5% imiquimod cream in a patient with classic Kaposi sarcoma

Department of Dermatology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Journal of Dermatological Case Reports 06/2012; 6(2):52-3. DOI: 10.3315/jdcr.2012.1099
Source: PubMed


The classic Kaposi sarcoma is most common in the Mediterranean population over 50 years of age and presents with reddish-brown papules and nodules particularly on the lower limbs. Treatment depends on the clinical presentation and extension of lesions. Imiquimod is as an immune response modifier with antiangiogenic activity.
We present a 74-year-old man with classic Kaposi sarcoma who had multiple, small, violaceous papules and nodules on the trunk and extremities with a history of 14 years. He complained particularly from plantar hyperkeratotic painful nodules. Treatment with imiquimod 5% cream under occlusion resulted with almost complete regression within 12 weeks. No local or systemic side effects were observed.
Topical imiquimod was a safe and effective therapy in our patient with classic Kaposi sarcoma.

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Available from: Işil Inanir, Jul 24, 2014