Cell culture: Soft gels select tumorigenic cells.
ABSTRACT Pliable gels of fibrin, a fibrous protein involved in blood clotting and
linked to cancer, select cells with high in vivo aggressiveness and
'stemness' from a pool of cancer cells.
- SourceAvailable from: Charlotte A. E. Hauser[Show abstract] [Hide abstract]
ABSTRACT: Hydrogels can offer cells an extracellular matrix-like growth environment which traditional culture methods cannot provide. Hydrogels therefore have great value in tissue engineering and regenerative medicine applications. In this article, we pay special attention to peptide-based hydrogels, which we further classified into short (≤20 residues) or ultrashort (≤7 residues) peptides. The design principles of these peptides are presented, and, based on their technical advantages and potential, biomedical applications are discussed.Materials Today 05/2014; 17(8). DOI:10.1016/j.mattod.2014.04.028 · 10.85 Impact Factor
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ABSTRACT: We reported in this study a visualized detection system for melamine based on supramolecular dydrogelations. A self-assembling peptide bearing the cyanuric acid (CA) was firstly designed and synthesized, which could form stable nanofiber dispersions but not hydrogels due to the weak inter-fiber interaction. The addition of melamine could cross-link the nanofibers by the hydrogen bonds between CA and melamine, thus leading to sol-gel phase transitions. Such sol-gel phase transition could also happen in milk and urine, and the hydrogel formation could be applied for the detection of melamine. Our detection method does not need sample pre-extraction process and any instruments and it can be directly used to detect melamine in foods and biological fluids by naked eyes. We believed our system might be applied for direct detection of melamine in remote places without instruments.Chemical Communications 09/2014; 50(85). DOI:10.1039/C4CC05826G · 6.72 Impact Factor