Article

Hepatoprotective effects of propolis extract on paracetamol‐induced liver damage in mice

Phytotherapy Research (impact factor: 2.09). 01/2006; 8(4):229 - 232. DOI:10.1002/ptr.2650080408 pp.229 - 232

ABSTRACT The effects of propolis extract were studied in a model of acute hepatotoxicity induced by a high oral dose (600 mg/kg) of paracetamol in mice. Propolis at doses of 25, 50 and 100 mg/kg i.p. decreased significantly the activity of alanine aminotransierase in serum, which was increased by paracetamol alone and increased the concentration of reduced glutathione in mouse liver, which is depleted by paracetamol. Propolis extract also reduced liver damage induced by paracetamol in mice, which was observed by optical and electron microscopy. The hepatoprotective effects of propolis were produced when administered 30 min before paracetamol or 2 h after it. It is concluded that propolis exerts some effects which resemble those of N-acetylcysteine, the well-known antidote of paracetamol.

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Keywords

acute hepatotoxicity induced
 
alanine aminotransierase
 
electron microscopy
 
hepatoprotective effects
 
mice
 
optical
 
paracetamol
 
Propolis
 
propolis exerts
 
well-known antidote