Passing the baton: the HIF switch.
ABSTRACT Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription factors, HIF-1 and HIF-2, which have both overlapping and unique target genes. HIF target gene activation is highly context specific and is not a reliable indicator of which HIF-α isoform is active. For example, in some cell lines, the individual HIFs have specific temporal and functional roles: HIF-1 drives the initial response to hypoxia (<24h) and HIF-2 drives the chronic response (>24h). Here, we review the significance of the HIF switch and the relation between HIF-1 and HIF-2 under both physiological and pathophysiological conditions.
Article: Clinical Relevance of Hif-1a, Cox-2, Leptin, and Prolactin as Hypoxic Markers in Breast Cancer[show abstract] [hide abstract]
ABSTRACT: Key words: Breast neoplasms, hypoxia-inducible factor-1α (HIF-1α), neovascularization, cyclooxygenase-2 (Cox-2), leptin (LEP), prolactin (PRL). abstract Background: Hypoxia is a critical event in tumor neovascularization process. It affects prolactin (PRL) and stimulates hypoxia-inducible factor-1α (HIF-1α) which can induce other genes such as cyclooxygenase-2 (Cox-2) and leptin (LEP).Austral - Asian Journal of Cancer. 10/2012; 11(4):237-246.