[Show abstract][Hide abstract] ABSTRACT: Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach.
Current Genomics 01/2015; 16(1):47-59. DOI:10.2174/1389202916666141223220551 · 2.34 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Vaccines are the most effective and sustainable means of preventing infectious diseases. Novel diagnostics would help customize the use of vaccines in subpopulations in which they would display enhanced safety and efficacy. This chapter focuses on giving a glimpse of the genetic status effect of vaccine immune response and how this could contribute to the development of novel vaccine candidates that are better directed and predicted relative to the genetic history of an individual and/or population. It provides a summary of genetic factors associated with human leukocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) in multiple classes of genes that provide immune response to vaccines. The immune response network theory, in its simplest form, is based on the premise “the response to a vaccine is the cumulative result of interactions driven by a host of genes and their interactions, and is theoretically predictable”.
Vaccines and Autoimmunity, 05/2015: pages 65-78; , ISBN: 9781118663431
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