Article

Systems biology of skeletal muscle: fiber type as an organizing principle.

Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Wiley Interdisciplinary Reviews Systems Biology and Medicine 07/2012; 4(5):457-73. DOI:10.1002/wsbm.1184 pp.457-73
Source: PubMed

ABSTRACT Skeletal muscle force generation and contraction are fundamental to countless aspects of human life. The complexity of skeletal muscle physiology is simplified by fiber type classification where differences are observed from neuromuscular transmission to release of intracellular Ca(2+) from the sarcoplasmic reticulum and the resulting recruitment and cycling of cross-bridges. This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction. WIREs Syst Biol Med 2012. doi: 10.1002/wsbm.1184 For further resources related to this article, please visit the WIREs website.

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Keywords

complex interactions
 
countless aspects
 
fiber type classification
 
human life
 
muscle force generation
 
resulting recruitment
 
sarcoplasmic reticulum
 
simplifying principle
 
Skeletal muscle force generation
 
skeletal muscle physiology
 
WIREs Syst Biol Med 2012